AI Article Synopsis
- - The study evaluated the connection between anogenital distance (AGD), a marker of prenatal androgen exposure, and the severity and prognosis of prostate cancer in 119 patients.
- - Researchers measured two types of AGD and conducted logistic regression analysis to determine their association with prostate cancer outcomes, focusing on biochemical recurrence and surgical specimen margins.
- - Results indicate that longer AGD, linked to higher prenatal androgen exposure, correlates with worse prognosis in prostate cancer cases.
Article Abstract
Objective: Anogenital distance (AGD), the distance from the centre of the anus to the genitals, is a sexually dimorphic phenotype in mammals. Several experimental studies have demonstrated that AGD is a biomarker of prenatal androgen exposure during the masculinisation period of development. The objective of this study was to assess the relationship between AGD (as an indirect marker of prenatal hormonal environment) and severity of the surgical specimen and prostate cancer (PCa) prognosis.
Methods: We conducted a cross-sectional study with a total of 119 PCa patients with confirmed biopsy of the tumour. Every participant underwent a physical examination where two variants of the AGD were assessed, a) from the anus to the cephalad insertion of the penis (AGDAP) and b) to the posterior base of the scrotum (AGDAS). To assess the association between both AGD and severity and PCa prognosis multiple logistic regression analysis was used.
Results: Longer AGDAS was significantly associated with biochemical recurrence and affected margins of the surgical specimen (OR: 2.5; IC 95%:1.2-5.5, and 2.8; IC 95%: 1.1-7.5, respectively).
Conclusions: Our findings suggest that a higher prenatal androgen exposure, resulting in a longer AGD, is associated with worse prognosis of PCa.
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