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The PEBP genes FLOWERING LOCUS T and TERMINAL FLOWER 1 modulate seed dormancy and size.
J Exp Bot
January 2025
Laboratory of Molecular Biology, Wageningen University and Research, 6708PB, Wageningen, The Netherlands.
The phosphatidylethanolamine-binding protein (PEBP) family members FLOWERING LOCUS T (FT) and TERMINAL FLOWER1 (TFL1) are major regulators of plant reproduction. In Arabidopsis, the FT/TFL1 balance defines the timing of floral transition and the determination of inflorescence meristem identity. However, emerging studies have elucidated a plethora of previously unknown functions for these genes in various physiological processes.
View Article and Find Full Text PDFPharmacological modulation of dopamine receptors reveals distinct brain-wide networks associated with learning and motivation in non-human primates.
J Neurosci
December 2024
Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029
The neurotransmitter dopamine (DA) has a multifaceted role in healthy and disordered brains through its action on multiple subtypes of dopaminergic receptors. How modulation of these receptors influences learning and motivation by altering intrinsic brain-wide networks remains unclear. Here we performed parallel behavioral and resting-state functional MRI experiments after administration of two different DA receptor antagonists in male and female macaque monkeys.
View Article and Find Full Text PDFTargeting STMN2 for neuroprotection and neuromuscular recovery in Spinal Muscular Atrophy: evidence from in vitro and in vivo SMA models.
Cell Mol Life Sci
December 2024
Department of Pathophysiology and Transplantation, Dino Ferrari Center, University of Milan, Milan, Italy.
The development of ground-breaking Survival Motor Neuron (SMN) replacement strategies has revolutionized the field of Spinal Muscular Atrophy (SMA) research. However, the limitations of these therapies have now become evident, highlighting the need for the development of complementary targets beyond SMN replacement. To address these challenges, here we explored, in in vitro and in vivo disease models, Stathmin-2 (STMN2), a neuronal microtubule regulator implicated in neurodegenerative diseases like Amyotrophic Lateral Sclerosis (ALS), as a novel SMN-independent target for SMA therapy.
View Article and Find Full Text PDFAn assessment of cryptocurrencies as a global commercial determinant of health.
Health Promot Int
December 2024
Nottingham Centre for Public Health and Epidemiology, School of Medicine, University of Nottingham, Hucknall Rd, Nottingham NG5 1PB, UK.
Through the commercial determinants of health framework, gambling has been identified as a powerful threat to health. This research critically examines cryptocurrency, which is promoted and sold as a highly gamblified product. Using the commercial determinants of health framework, the multifaceted ways in which cryptocurrency firm operations may impact health outcomes are highlighted.
View Article and Find Full Text PDFNavigating Queer Narratives: Student Teachers' Perspectives on LGBT+ Picture Books.
J Homosex
November 2024
School of Education, Leeds Trinity University, Leeds, UK.
This study employs a queer theoretical framework to explore three student teachers' interpretations and perceptions of two LGBT+ picture books, including their considerations on integrating these texts into classroom pedagogy. The participants are nearing completion of their initial teacher training at a university in the northern part of England. The picture books that are the focus of the study were purposefully selected owing to their exploration of varied queer themes.
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