AI Article Synopsis
- - The rising issue of antimicrobial resistance has prompted researchers to seek new compounds with unique structures that can combat bacteria.
- - This report focuses on the draft genome sequence of strain VG4, isolated from Red Sea sediments, known for producing antimicrobial metabolites.
- - Genomic analysis of VG4 shows it has five gene clusters that could lead to the creation of bioactive compounds like polyketides and nonribosomal peptides, with predicted structures based on computational methods.
Article Abstract
With antimicrobial resistance on the rise, the discovery of new compounds with novel structural scaffolds exhibiting antimicrobial properties has become an important area of research. Such compounds can serve as starting points for the development of new antimicrobials. In this report, we present the draft genome sequence of the strain VG4, isolated from Red Sea sediments, that produces metabolites with antimicrobial properties. A genomic analysis reveals that it carries at least five gene clusters that have the potential to direct biosynthesis of bioactive secondary metabolites such as polyketides and nonribosomal peptides. By using approaches, we predict the structure of these metabolites.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127377 | PMC |
| http://dx.doi.org/10.1016/j.btre.2018.e00278 | DOI Listing |
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