Acquired ophthalmoplegia can represent a harbinger of vision and life-threatening disease. Recognition of select clinical "red flags" on history or examination can facilitate early diagnosis. This article reviews relevant clinical pearls for the detection of dire causes of acquired ophthalmoplegia in adults including myasthenia gravis, carotid cavernous fistula, giant cell arteritis, and thiamine deficiency. Prompt treatment of all of these disorders can either reverse or halt the progression of visual manifestations.
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http://dx.doi.org/10.1080/2576117X.2017.1420134 | DOI Listing |
Int J Mol Sci
June 2024
Neurology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Eur J Ophthalmol
January 2025
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, China.
Purpose: Isolated acquired superior rectus palsy (ASRP) is extremely rare. The goal of this report is to describe the clinical manifestations and surgical protocols for treatment of isolated traumatic ASRP.
Design: Retrospective observational case series.
Eur J Hum Genet
August 2024
Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, 40138, Bologna, Italy.
COQ7 pathogenetic variants cause primary CoQ deficiency and a clinical phenotype of encephalopathy, peripheral neuropathy, or multisystemic disorder. Early diagnosis is essential for promptly starting CoQ supplementation. Here, we report novel compound heterozygous variants in the COQ7 gene responsible for a prenatal onset (20 weeks of gestation) of hypertrophic cardiomyopathy and intestinal dysmotility in a Bangladesh consanguineous family with two affected siblings.
View Article and Find Full Text PDFCureus
March 2024
Geriatric Medicine, Queen's Hospital Burton, Burton-on-Trent, GBR.
Cerebral venous sinus thrombosis (CVST) is a rare cause of strokes and is most common in younger patients particularly those less than 50 years of age. It is more common in females than in males and is known to be associated with pregnancy, puerperium, oral contraception, congenital and acquired thrombophilia, and malignancy. Less commonly, it has been shown to be associated with infections and more recently has been found to be associated with COVID-19 infection with thrombocytopenia and the COVID-19 vaccine AstraZeneca.
View Article and Find Full Text PDFMedicine (Baltimore)
April 2024
Department of Ophthalmology, Hangzhou Red Cross Hospital (Zhe Jiang Chinese Medicine and Western Medicine Integrated Hospital), Hangzhou, Zhejiang, P.R. China.
Background: Previous reports revealed that patients with acquired paralytic strabismus caused by central nervous system diseases are primarily affected by the etiology and treatment of the condition. Strabismus correction for these acquired paralytic strabismus should be performed as soon as the primary disease has been stabilized for 6 months in order to archive a favorable surgical outcome.
Case: We followed an infrequent case of longer-lasting supranuclear ophthalmoplegia secondary to brain stem cavernoma.
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