A low molecular weight substance which behaves like ouabain as inhibitor of brain membrane Na-K-ATPase and 3H-ouabain binding was found in plasma after saline expansion of extracellular fluid or angiotensin II infusion into the third brain ventricle in the rat. Intracerebroventricular infusion of angiotensin II antagonist, saralasin, blocks the increase of the Na-K-ATPase inhibitor produced by infusion of angiotensin II into the third ventricle or extracellular fluid saline expansion.

Download full-text PDF

Source
http://dx.doi.org/10.3109/10641968609044082DOI Listing

Publication Analysis

Top Keywords

extracellular fluid
12
saline expansion
12
saralasin blocks
8
fluid saline
8
na-k-atpase inhibitor
8
infusion angiotensin
8
angiotensin
4
blocks angiotensin
4
angiotensin extracellular
4
expansion na-k-atpase
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!