Background And Objective: Accurate localization of heart beats in phonocardiogram (PCG) signal is very crucial for correct segmentation and classification of heart sounds into S1 and S2. This task becomes challenging due to inclusion of noise in acquisition process owing to number of different factors. In this paper we propose a system for heart sound localization and classification into S1 and S2. The proposed system introduces the concept of quality assessment before localization, feature extraction and classification of heart sounds.
Methods: The signal quality is assessed by predefined criteria based upon number of peaks and zero crossing of PCG signal. Once quality assessment is performed, then heart beats within PCG signal are localized, which is done by envelope extraction using homomorphic envelogram and finding prominent peaks. In order to classify localized peaks into S1 and S2, temporal and time-frequency based statistical features have been used. Support Vector Machine using radial basis function kernel is used for classification of heart beats into S1 and S2 based upon extracted features. The performance of the proposed system is evaluated using Accuracy, Sensitivity, Specificity, F-measure and Total Error. The dataset provided by PASCAL classifying heart sound challenge is used for testing.
Results: Performance of system is significantly improved by quality assessment. Results shows that proposed Localization algorithm achieves accuracy up to 97% and generates smallest total average error among top 3 challenge participants. The classification algorithm achieves accuracy up to 91%.
Conclusion: The system provides firm foundation for the detection of normal and abnormal heart sounds for cardiovascular disease detection.
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http://dx.doi.org/10.1016/j.cmpb.2018.07.006 | DOI Listing |
Res Child Adolesc Psychopathol
January 2025
Nutrition and Mental Health Research Group (NUTRISAM), Universitat Rovira I Virgili (URV), Carretera de Valls, S/N, 43007, Tarragona, Spain.
The aim of this study is to investigate the impact of using probiotics with strains related to dopamine and gamma-aminobutyric acid production on clinical features of autism spectrum disorder (ASD) and/or attention deficit/hyperactivity disorder (ADHD). This randomized, controlled trial involved 38 children with ADHD and 42 children with ASD, aged 5-16 years, who received probiotics (Lactiplantibacillus plantarum and Levilactobacillus brevis 109/cfu/daily) or placebo for 12 weeks. Parent-reported symptoms were assessed using Conners' 3rd-Ed and the Social Responsiveness Scale Test, 2nd-Ed (SRS-2), and children completed the Conners Continuous Performance Test, 3rd-Ed (CPT 3) or Conners Kiddie CPT, 2nd-Ed (K-CPT 2).
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar, Punjab, India.
Neuropathic pain, a challenging condition often associated with diabetes, trauma, or chemotherapy, impairs patients' quality of life. Current treatments often provide inconsistent relief and notable adverse effects, highlighting the urgent need for safer and more effective alternatives. This review investigates marine-derived bioactive compounds as potential novel therapies for neuropathic pain management.
View Article and Find Full Text PDFEur J Nucl Med Mol Imaging
January 2025
Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, China.
Purpose: Since fibroblast activation protein (FAP), one predominant biomarker of cancer associated fibroblasts (CAFs), is highly expressed in the tumor stroma of various epidermal-derived cancers, targeting FAP for tumor diagnosis and treatment has shown substantial potentials in both preclinical and clinical studies. However, in preclinical settings, tumor-bearing mice exhibit relatively low absolute FAP expression levels, leading to challenges in acquiring high-quality PET images using radiolabeled FAP ligands (FAPIs) with low molar activity, because of which a saturation effect in imaging is prone to happen. Moreover, how exactly the molar dose of FAPI administered to a mouse influences the targeted PET imaging and radiotherapy remains unclear now.
View Article and Find Full Text PDFEur J Orthop Surg Traumatol
January 2025
Southwest of London Orthopaedic Elective Centre, Epsom, UK.
Background: The aim was to assess whether the postoperative Oxford Hip Score (OHS) demonstrated a ceiling effect at 1 or 2 years after total hip arthroplasty (THA) and to identify which patients are more likely to achieve a ceiling score and whether this limits assessment of their outcome.
Methods: A retrospective cohort of 7871 patients undergoing primary THA was identified from an established arthroplasty database. Patient demographics, ASA grade, socioeconomic status, OHS and EuroQol questionnaire were collected preoperatively and at 1 and 2 years postoperatively.
Environ Manage
January 2025
United States Department of Agriculture, Animal Plant Health Inspection Service, Wildlife Services, Fort Collins, CO, USA.
The great horned owl (Bubo virginianus) is a generalist predator that inhabits wide-ranging territories that are relatively stable throughout the year. These owls are also involved in a variety of human-owl conflicts, including killing of domestic poultry, predating colonially nesting seabirds and shorebirds, and pose a hazard to safe aircraft operations. Managing these conflict situations presents unique challenges as great horned owls are nocturnally active and occupy a wide range of habitats.
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