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Placenta-conditioned extracellular matrix (ECM) activates breast cancer cell survival mechanisms: A key for future distant metastases. | LitMetric

AI Article Synopsis

  • The extracellular matrix (ECM) influences cancer cell behavior, with normal cells undergoing cell death (anoikis) when they fail to attach to it, while cancer cells are often resistant to this process, aiding their spread.
  • Our research indicates that the placenta modifies its ECM to prevent breast cancer cell attachment, fostering their movement and clustering, which explains the rarity of breast cancer metastasis to the placenta despite advanced stages during pregnancy.
  • We found that interaction with the placental ECM activates survival pathways in breast cancer cells, promoting autophagy and drug resistance, particularly by altering integrin α5 levels, positioning it as a potential target for cancer therapy.

Article Abstract

The extracellular matrix (ECM) affects cancer cell characteristics. Inability of normal epithelial cells to attach to the ECM induces apoptosis (anoikis). Cancer cells are often anoikis resistant, a prerequisite for their metastatic spread. Previously we demonstrated that the placenta manipulates its surrounding ECM in a way that prevents breast cancer cells (BCCL) attachment and induces their motility and aggregation. This fits with the fact that although breast cancer during pregnancy is often advanced, metastasis to the placenta is rarely observed. Placental intervillous space provides suitable conditions for cancer cell arrival. Yet, the outcome of the short communication between the placental ECM to the BCCL and its effect on BCCL malignant potential are unknown, and are the focus of our study. In the current study we analyzed the effect of placental ECM on BCCL survival pathways and drug resistance. Microarray analysis suggested activation of the NF-κB and stress response pathways. Indeed, the placenta-conditioned ECM induced autophagy in ERα + BCCL, inactivated the NF-κB inhibitor (IκB) and increased integrin α5 in the BCCL. The autophagy mediated MCF-7 and T47D migration and the placental ECM-BCCL interactions reduced the BCCL sensitivity to Taxol. We also demonstrated by using siRNA that integrin α5 was responsible for the MCF-7 autophagy and suggest this molecule as a suitable target for therapy.

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Source
http://dx.doi.org/10.1002/ijc.31861DOI Listing

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