Gaseous transmitters contribution in blood oxygen transport function modification under the influence of the magnetic field was studied. It is found, that irradiation of the tail artery of rats for 10 days during 10 minutes increases p50 value, indicating a decrease in the hemoglobin affinity for oxygen and is accompanied by increased concentrations of nitrate/nitrite, and hydrogen sulfide. Administration of L-arginine and nitroglycerin during magnetic field action is accompanied by a decrease of hemoglobin affinity for oxygen, which is absent when NO-synthase enzyme inhibitor (L-NAME) is added. These data suggest an important role in the formation of blood oxygen transport function such gaseous transmitters as nitrogen monoxide and hydrogen sulfide.
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Curr Res Toxicol
October 2024
Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, PR China.
Formaldehyde (FA) long term exposure leads to abnormal pulmonary function and small airway obstruction of the patients. Hydrogen sulfide (HS) is one of the recognized gaseous transmitters involved in a wide range of cellular functions. It is unknown the involvement of HS in FA-induced lung injury.
View Article and Find Full Text PDFInt J Biol Macromol
September 2024
Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Light Industry and Food, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China. Electronic address:
Hydrogen sulfide (HS) is considered one of the most important gaseous transmitters in the metabolic system, and the abnormal concentration of HS is associated with a variety of diseases. Up to now, it is still a challenge to develop a portable assay for HS even though the research about the detection of HS is booming. Herein, a novel bifunctional dialdehyde-cellulose fluorescent probe DAC-DPD was prepared with high selectivity and sensitivity to HS with colorimetric and fluorescent "turn-on" characteristics, and the limit of detection (LOD) of DAC-DPD for HS was 0.
View Article and Find Full Text PDFExp Cell Res
August 2024
Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, School of Stomatology, Henan University, Kaifeng, Henan, 475004, China; Kaifeng Municipal Key Laboratory of Cell Signal Transduction, School of Basic Medical Sciences, Henan University, Kaifeng, Henan, 475004, China; Department of Stomatology, Huaihe Hospital of Henan University, School of Stomatology, Henan University, Kaifeng, Henan, 475004, China. Electronic address:
Pharmacol Biochem Behav
October 2024
Laboratório de Neurofarmacologia e Biofísica, Universidade do Estado do Pará, Campus VIII, Marabá, PA, Brazil; Departamento de Morfologia e Ciências Fisiológicas, Universidade do Estado do Pará, Campus VIII, Marabá, PA, Brazil.
Nitric oxide (NO) is a molecule involved in plasticity across levels and systems. The role of NOergic pathways in stress-induced sensitization (SIS) of behavioral responses, in which a particular stressor triggers a state of hyper-responsiveness to other stressors after an incubation period, was assessed in adult zebrafish. In this model, adult zebrafish acutely exposed to a fear-inducing conspecific alarm substance (CAS) and left undisturbed for an incubation period show increased anxiety-like behavior 24 h after exposure.
View Article and Find Full Text PDFJ Clin Med
June 2024
Department of Internal Medicine and Family Medicine, Collegium Medicum, Jan Kochanowski University in Kielce, 25-369 Kielce, Poland.
The sulfide-hydrogen sulfide brine balneotherapy (HSBB), including a combination of dissolved hydrogen sulfide (HS) gas, inorganic sulfur ions (S), and hydrosulfide ions (HS), is one of the most important and most effective forms of spa treatment in patients with osteoarticular disorders (OADs). Some cardiovascular diseases (CVDs) are often considered to be contraindications to HSBB since the presence of thiol groups may lead to an increased quantity of reactive oxygen species (ROS), which damage the vascular endothelium, and endothelial dysfunction is considered to be the main cause of atherosclerosis. However, there are a number of literature reports suggesting this theory to be false.
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