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Rational Design of Advanced Gene Delivery Carriers: Macrophage Phenotype Matters.
Adv Mater
January 2025
Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Nucleic acid delivery in hard-to-transfect macrophages have attracted increasing attention in diverse applications such as defence against bacterial infection. Regulated by microenvironments in specific applications, macrophages have a heterogenous nature and exist in different phenotypes with diverse functions, e.g.
View Article and Find Full Text PDFHigh-Efficiency Enzyme Assay and Screening of Enzyme-Inhibiting Nanomaterials Using Capillary Electrophoresis with Hierarchically Porous Metal-Organic Framework-Based Immobilized Enzyme Microreactor.
Anal Chem
October 2024
School of Pharmacy, Southwest Medical University, Luzhou 646000, China.
Enzyme-inhibiting nanomaterials have significant potential for regulating enzyme activity. However, a universal and efficient method for systematically screening and evaluating the inhibitory effects of various nanomaterials on drug target enzymes has not been established. While the integrated technique of immobilized enzyme microreactor (IMER) with capillary electrophoresis (CE) serves as an effective tool for enzyme analysis, it still faces challenges such as low enzyme loadability, unsatisfactory stability, and limited applicability.
View Article and Find Full Text PDFCu-Atom Locations in Rocksalt SnTe Thermoelectric Alloy.
Adv Mater
November 2024
School of Mechanical and Mining Engineering, The University of Queensland, Brisbane, QLD, 4072, Australia.
The development of functional thermoelectric materials requires direct evidence of dopants' locations to rationally design the electronic and phononic structure of the host matrix. In this study, Cs-corrected scanning transmission electron microscopy and energy dispersive X-ray spectroscopy is employed at the atomic scale to identify Cu atoms' locations in a Cu-doped SnTe thermoelectric alloy. It is revealed that Cu atoms in the rocksalt SnTe form solid solutions at both Sn and Te sites, contrary to their electronegativity order and the intentional Cu doping at Sn sites.
View Article and Find Full Text PDFEmpowering probiotics with high xanthine transport for effective hyperuricemia management.
Gut Microbes
September 2024
Laboratory of Biosystems and Microanalysis, State Key Laboratory of Bioreactor Engineering, Institute of Engineering Biology and Health, East China University of Science and Technology, Shanghai, China.
Hyperuricemia, a prevalent metabolic disorder, poses a susceptibility to various complications. The conventional pharmacotherapeutic approaches for hyperuricemia often entail notable adverse effects, posing substantial clinical challenges. Hence, the imperative lies in the development of novel, safe and effective strategies for preventing and treating hyperuricemia.
View Article and Find Full Text PDFPreparation and properties of double-layer phenolic/polyurethane coated isophorone diisocyanate self-healing microcapsules.
Sci Rep
September 2024
CAS Key Laboratory of Carbon Materials, Institute of Coal Chemistry, Chinese Academy of Sciences, Taiyuan, 030001, China.
Article Synopsis
- * Researchers encapsulated these microcapsules in a double-layer of phenolic and polyurethane to enhance their mechanical and thermal performance, revealing substantial improvements in stability and aging properties.
- * The enhanced epoxy coating with added microcapsules showed effective self-healing capabilities, with a 57.9% healing efficiency from crack damage, and prevented corrosion when tested in a saline environment, showcasing the benefits of this innovative design approach.
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