AI Article Synopsis
- Marburg virus (MARV) leads to severe outbreaks of hemorrhagic fever in sub-Saharan Africa with very high mortality rates.
- The study reveals that STAT2 knockout Syrian hamsters can be infected by various wild-type MARV variants, which causes severe disease similar to that seen in humans.
- This research presents the STAT2 knockout hamster as a new small animal model for studying severe MARV infections, eliminating the need for the virus to adapt to infect immunocompetent animals.
Article Abstract
Marburg virus (MARV; family Filoviridae) causes sporadic outbreaks of Marburg hemorrhagic fever in sub-Saharan Africa with case fatality rates reaching 90%. Wild-type filoviruses, including MARV and the closely related Ebola virus, are unable to suppress the type I interferon response in rodents, and therefore require adaptation of the viruses to cause disease in immunocompetent animals. In the current study, we demonstrate that STAT2 knockout Syrian hamsters are susceptible to infection with different wild-type MARV variants. MARV Musoke causes a robust and systemic infection resulting in lethal disease. Histopathological findings share features similar to those observed in human patients and other animal models of filovirus infection. Reverse-transcription polymerase chain reaction analysis of host transcripts shows a dysregulation of the innate immune response. Our results demonstrate that the STAT2 knockout hamster represents a novel small animal model of severe MARV infection and disease without the requirement for virus adaptation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249581 | PMC |
| http://dx.doi.org/10.1093/infdis/jiy457 | DOI Listing |
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