AI Article Synopsis
- - Peptide 1 containing an Aβ42 core self-assembles in water, forming nanoparticles that can be influenced by temperature and solvent changes, leading to distinct structures like nanofibers and helical bundles.
- - Mechanical agitation allows researchers to create shorter, uniform seeds that help guide the growth of supramolecular peptide nanofibers through a specific polymerization process.
- - This ability to control the length and structure of the nanofibers is used to enhance the mechanical properties of hydrogel materials, making them potentially useful for various applications.
Article Abstract
Peptide 1 with an Aβ42 amyloid nucleating core demonstrates step-wise self-assembly in water. Variation of temperature or solvent composition arrests the self-assembly to give metastable nanoparticles, which undergo self-assembly on gradual increase in temperature and eventually produce kinetically controlled nanofibers and thermodynamically stable twisted helical bundles. Mechanical agitation of the fibers provided access to short seeds with narrow polydispersity index, which by mediation of seeded supramolecular polymerization establishes perfect control over the length of the nanofibers. Such pathway dependence and the length control of the supramolecular peptide nanofibers is exploited to tune the mechanical strength of the resulting hydrogel materials.
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| http://dx.doi.org/10.1039/c8cc06266h | DOI Listing |
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