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The reversal effect of physical exercise on aging-related increases in APPL2 content in skeletal muscle. | LitMetric

The reversal effect of physical exercise on aging-related increases in APPL2 content in skeletal muscle.

Life Sci

Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira, SP, Brazil; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center (OCRC), University of Campinas, Campinas, SP, Brazil; CEPECE - Center of Research in Sport Sciences, School of Applied Sciences, University of Campinas (UNICAMP), Limeira, SP, Brazil. Electronic address:

Published: October 2018

AI Article Synopsis

  • The study aimed to assess how aging affects adiponectin signaling in cells and the potential benefits of physical exercise on this process.
  • Fischer 344 rats of different ages and exercise regimens were used, revealing that older rats had glucose intolerance without higher fat accumulation, but exercise reversed this issue.
  • The findings suggest that short-term exercise reduces certain protein levels linked to glucose metabolism, improving glucose tolerance in older rats, highlighting exercise as a valuable non-drug treatment for age-related health issues.

Article Abstract

Aims: The aim of this study was to evaluate the effects of aging on intracellular adiponectin signaling and the possible therapeutic effect of physical exercise.

Main Methods: Fischer 344 rats were distributed in the following groups: Young (3 months old); Sedentary Old (Old, 27 months old); and Old Exercised (Old-Exe, 27 months old), which were subjected to a short-term exercise training protocol.

Key Findings: The results showed that the old rats presented glucose intolerance without increased adiposity. However, short-term exercise training reversed this disorder, which was associated with a decrease in the pleckstrin homology domain, phosphotyrosine-binding domain, and leucine zipper motif (APPL) isoform 2 (APPL2) content. The APPL isoform 1 (APPL1) and TRB3 (Tribbles homolog 3) contents were not altered. Akt phosphorylation was only increased in the old exercised rats. There was a reduction in the content of adiponectin receptor 1 in the old rats.

Significance: The short-term exercise training protocol was able to decrease APPL2 content in the skeletal muscle, which was accompanied by an improvement in the glucose tolerance of the old Fischer 344 rats. These findings provide new evidence supporting the role of physical exercise as a non-pharmacological therapeutic intervention to attenuate age-related deficits.

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Source
http://dx.doi.org/10.1016/j.lfs.2018.09.006DOI Listing

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