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Ulcerative Necrobiosis Lipoidica Involving Atypical Site Over Upper Limb.
Indian J Dermatol
October 2024
Department of Pathology, Command Hospital, Kolkata, West Bengal, India.
Necrobiotic Pulmonary Nodules in Ulcerative Colitis: A Rare Case Report.
Am J Case Rep
December 2024
Division of Thoracic Surgery, Imperial College NHS Healthcare Trust and National Heart and Lung Institute, London, United Kingdom.
BACKGROUND Necrobiotic pulmonary nodules represent an exceptionally rare extraintestinal manifestation of inflammatory bowel disease (IBD), comprising conditions such as Crohn's disease and ulcerative colitis. These nodules pose significant diagnostic challenges, often mimicking autoimmune pathologies like sarcoidosis, rheumatoid arthritis, and other granulomatous diseases, thereby complicating the clinical management of affected patients. The rarity and nonspecific clinical presentation of necrobiotic pulmonary nodules necessitate a reliance on a combination of radiological and histological findings for accurate diagnosis.
View Article and Find Full Text PDFThe Differential Diagnosis of Leg Ulcers.
Dtsch Arztebl Int
November 2024
Department of Dermatology, Venereology and Allergology, University Hospital Essen, University Duisburg-Essen, Essen, Germany; Department of Vascular Medicine, Angiology, HELIOS Klinikum Krefeld GmbH, Krefeld, Germany.
Article Synopsis
- Leg ulcers, primarily located below the knee, can stem from various causes with around 80% resulting from chronic venous insufficiency (CVI) or peripheral arterial occlusive disease (PAOD), necessitating diverse medical specialists for treatment.
- The diagnostic approach follows the ABCDE rule, which includes personalized history-taking, bacteriological testing, clinical exams, and additional tests to accurately identify the cause of the ulcer, such as vascular issues or other diseases.
- Effective treatment relies on prompt differential diagnosis, highlighting the need for collaboration among different medical specialties due to the complexity of leg ulcers and the challenges posed by limited high-quality research.
Monoclonal Antibodies in the Management of Inflammation in Wound Healing: An Updated Literature Review.
J Clin Med
July 2024
Department of Dermatology, University of Pisa, 56126 Pisa, Italy.
Article Synopsis
- - Chronic wounds are challenging to treat due to their complicated biology, and while monoclonal antibodies (mAbs) show promise as a new treatment option, more comprehensive data on their effectiveness is needed.
- - A literature review found that mAbs were effective for various chronic wound types, especially in conditions like pyoderma gangrenosum and lipoid necrobiosis, with a total of fourteen different mAbs being analyzed.
- - Although mAbs can provide potential benefits for chronic wounds resistant to standard treatments, no single target molecule can be pinpointed due to the complex nature of wound healing, suggesting that mAbs should be used selectively for tough cases.
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