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Histological staining of tick bite skin biopsies for spirochetes and Powassan virus RNA.
Microbiol Spectr
January 2025
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
is a vector of several human pathogens in the United States, including the cause of Lyme disease, and Powassan virus (POWV), an emerging cause of severe encephalitis. Skin biopsies from tick bite sites are frequently collected and tested for the presence of spirochetes ( spp.), which remain elusive.
View Article and Find Full Text PDFBarriers and facilitators for the implementation of delayed-prescription of antibiotics in family medicine: a qualitative study.
BMC Health Serv Res
January 2025
Faculty of Communication, Culture and Society, Università Della Svizzera Italiana, Lugano, Switzerland.
Background: Delayed prescription is a strategy used in various countries to reduce antibiotic overuse and contend the effects of antibiotic resistance; however this practice is not yet used in Switzerland. The present qualitative study was thus conducted to investigate Swiss patients' attitudes towards the possible implementation of delayed prescription.
Method: Five focus groups with the general population based on a fixed script of questions to elicit opinions on delayed prescription.
Resistive memory-based zero-shot liquid state machine for multimodal event data learning.
Nat Comput Sci
January 2025
Key Lab of Fabrication Technologies for Integrated Circuits and Key Laboratory of Microelectronic Devices and Integrated Technology, Institute of Microelectronics of the Chinese Academy of Sciences, Beijing, China.
The human brain is a complex spiking neural network (SNN) capable of learning multimodal signals in a zero-shot manner by generalizing existing knowledge. Remarkably, it maintains minimal power consumption through event-based signal propagation. However, replicating the human brain in neuromorphic hardware presents both hardware and software challenges.
View Article and Find Full Text PDFDynamic changes and influential factors of blowouts in a desert artificial ecosystem at the southeastern margin of Tengger Desert in China.
J Environ Manage
January 2025
College of Forestry and Prataculture, Ningxia University, Yinchuan 750021, China.
The wind-blown sand protection system in the Shapotou section of the Baotou-Lanzhou Railway is a representative artificial ecosystem in a desert region. Over the past 70 years, this system has transformed mobile dunes into fixed dunes through vegetation succession, relying solely on natural rainfall without additional irrigation. However, ecosystem sustainability has been endangered by the emergence of numerous blowouts.
View Article and Find Full Text PDFOxidative/Nitrosative Stress and Brain Involvement in Sepsis: A Relationship Supported by Immunohistochemistry.
Medicina (Kaunas)
November 2024
SIC Medicina Legale, Via Potito Petrone, 85100 Potenza, Italy.
: A large amount of recent evidence suggests that cellular inability to consume oxygen could play a notable part in promoting sepsis as a consequence of mitochondrial dysfunction and oxidative stress. The latter could, in fact, represent a fundamental stage in the evolution of the "natural history" of sepsis. Following a study previously conducted by the same working group on heart samples, the present research project aims to evaluate, through an immunohistochemical study, the existence and/or extent of oxidative stress in the brains of subjects who died due to sepsis and define, after reviewing the literature, its contribution to the septic process to support the use of medications aimed at correcting redox anomalies in the management of septic patients.
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