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Statistical optimization of pectinases from thermophilic Aspergillus fumigatus BT-4 employing response surface methodology through submerged fermentation using agricultural wastes.
BMC Biotechnol
January 2025
School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, China.
Background: In this study, thermophilic pectinase-producing strains were isolated. Among all the isolates, strain No. 4 was identified as Aspergillus fumigatus BT-4 based on its morphology and 18 S rDNA analysis.
View Article and Find Full Text PDFLuminescent Carbon Dots From Biomass Waste for the Sensitive Determination of Ascorbic Acid in Tablet Dosage Forms.
Luminescence
January 2025
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Misr International University, Cairo, Egypt.
Affordable and eco-friendly green spectrofluorometric (FL) methods can enhance the safety and cost-effectiveness of quality assurance and control in ascorbic acid (ASA) formulations. However, most current techniques for ASA analysis have faced challenges like complexity, delayed response times, low throughput, time-consuming procedures, and requirements for expensive equipment and hazardous chemicals for analyte modification. The study is aimed at producing natural carbon quantum dots (NACQDs) from pumpkin seed peels (PSPs), a natural waste material, using a rapid microwave-assisted method.
View Article and Find Full Text PDFTechnical, economic, and environmental assessment of CO₂ ship transport in carbon capture and storage.
J Environ Manage
December 2024
Professor of Geochemistry, School of Ocean & Earth Science, National Oceanography Centre Southampton and Director of the Southampton Marine & Maritime Institute, University of Southampton, United Kingdom. Electronic address:
Article Synopsis
- CO shipping is essential for advancing Capture Utilization and Storage (CCUS) in the UK, with a study evaluating the maritime transport of approximately 5.9 million tons of CO2 annually, comparable to removing 1.3 million cars from roads.
- The study emphasizes the importance of economies of scale and finds that low-pressure vessels are more cost-effective than medium-pressure ones, with liquefaction and transportation costs making up 73% of total expenses.
- It highlights potential cost-reduction strategies, such as port incentives and renewable energy use, while also noting that electricity prices and discount rates are crucial factors affecting the financial viability of CO2 transport projects.
DREAM: an adaptive, randomised, placebo-controlled trial of duloxetine for reducing leg pain in people with chronic sciatica-trial protocol.
BMJ Open
December 2024
Institute for Musculoskeletal Health, Sydney Local Health District, Sydney, New South Wales, Australia.
Introduction: Sciatica is a debilitating condition that often becomes chronic, and for which there are few effective treatment options. Treatments such as the anti-depressant duloxetine have shown promise, but the evidence is inconclusive. We are describing a high quality, definitive trial to investigate the efficacy, safety and cost-effectiveness of duloxetine in chronic sciatica.
View Article and Find Full Text PDFExome Sequencing in the Diagnostic Pathway for Suspected Rare Genetic Diseases: Does the Order of Testing Affect its Cost-Effectiveness?
Appl Health Econ Health Policy
December 2024
Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, AB, T2N 4Z6, Canada.
Background: Patients with suspected rare diseases often experience lengthy and uncertain diagnostic pathways. This study aimed to estimate the cost-effectiveness of exome sequencing (ES) in different positions in the diagnostic pathway for patients suspected of having a rare genetic disease.
Methods: Data collected retrospectively from 305 patients suspected of having a rare genetic disease (RGD), who received clinical-grade ES and participated in the Canadian multicentre Care4Rare-SOLVE study, informed a discrete event simulation of the diagnostic pathway.
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