AI Article Synopsis
- Glomerulonephritis (GN) linked to rheumatoid arthritis has various forms, but RBC-associated complement 3 (C3)-GN has not been previously reported.
- C3GN results from issues in the alternative complement pathway, unlike typical autoimmune diseases that activate the classic pathway and cause kidney damage.
- A patient with a long history of rheumatoid arthritis showed symptoms like edema and proteinuria; after a biopsy confirmed C3GN, hormone treatment successfully led to complete recovery.
Article Abstract
Glomerulonephritis (GN) caused by rheumatoid arthritis may manifest as various pathological types; however, to the best of our knowledge, rheumatoid arthritis-associated complement 3 (C3)-GN has not been reported by any previous studies. C3GN is caused by dysregulation of the alternative pathway of complements, which is completely different from activation of the classic pathway of a typical autoimmune disease to cause renal damage. The present study describes a patient with a history of rheumatoid arthritis for 18 years, who presented with edema, proteinuria, hematuria, hypoproteinemia and a hypocomplementemic state. The pathological diagnosis was C3GN based on histological examination of a renal biopsy specimen. Hormone treatment on its own appeared to be effective and achieved complete clinical remission, while the follow-up of the condition remained stable.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122502 | PMC |
| http://dx.doi.org/10.3892/etm.2018.6476 | DOI Listing |
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