The spatial-numerical association of response codes (SNARC) effect refers to the phenomenon that responses involving small numbers are faster with the left hand and responses involving large numbers are faster with the right hand. Previous studies have investigated the mechanism of the SNARC effect only when the time sequence is induced by centrally presented successive numbers. No study has investigated the mechanism of the SNARC effect when the spatial sequence is induced. Given that the induction of a spatial sequence together with a time sequence provides a new temporary reference for the serial order to be coded in working memory (WM), it would be interesting to examine the SNARC effect when both the time sequence and spatial sequence are induced. Therefore, a novel priming paradigm that simultaneously induced the time sequence and spatial sequence was employed in the present study to investigate the mechanism of the SNARC effect. Specifically, the time sequence and spatial sequence were induced by presenting a series of self-paced successive numbers, centrally or in a left-to-right or right-to-left direction, on the screen. Following the presentation of successive numbers, the probe number was centrally presented on the screen and university students were asked to distinguish to which time sequence or spatial sequence the probe number belonged by pressing a specified key of a qwerty keyboard. The results indicated that (1) the SNARC effect simultaneously appeared in the processing of the number magnitude and time sequence when only the time sequence was induced. (2) The SNARC effect disappeared in the processing of the time sequence; however, the SNARC effect coexisted in the processing of the numerical magnitude and spatial sequence when the spatial sequence was induced and participants performed a time sequence relevant task. (3) The SNARC effect coexisted in the processing of the numerical magnitude, time sequence, and spatial sequence when the spatial sequence was induced and participants performed a spatial sequence relevant task. Based on these results, we conclude that whether the SNARC effect coexists in the processing of the numerical magnitude, the time sequence and spatial sequence were influenced by the spatial sequence and relevant task. The results further support the mental whiteboard hypothesis and extended the WM account. Implications for theories on the SNARC effect were discussed.
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http://dx.doi.org/10.3389/fpsyg.2018.01558 | DOI Listing |
Nat Commun
December 2024
School of Data Science, The Chinese University of Hong Kong-Shenzhen, Shenzhen, China.
Recently, RNA velocity has driven a paradigmatic change in single-cell RNA sequencing (scRNA-seq) studies, allowing the reconstruction and prediction of directed trajectories in cell differentiation and state transitions. Most existing methods of dynamic modeling use ordinary differential equations (ODE) for individual genes without applying multivariate approaches. However, this modeling strategy inadequately captures the intrinsically stochastic nature of transcriptional dynamics governed by a cell-specific latent time across multiple genes, potentially leading to erroneous results.
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December 2024
Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Biological systems are complex, encompassing intertwined spatial, molecular and functional features. However, methodological constraints limit the completeness of information that can be extracted. Here, we report the development of INSIHGT, a non-destructive, accessible three-dimensional (3D) spatial biology method utilizing superchaotropes and host-guest chemistry to achieve homogeneous, deep penetration of macromolecular probes up to centimeter scales, providing reliable semi-quantitative signals throughout the tissue volume.
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December 2024
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Hodgkin Reed-Sternberg (HRS) cells of classic Hodgkin lymphoma (cHL), like many solid tumors, elicit ineffective immune responses. However, patients with cHL are highly responsive to PD-1 blockade, which largely depends on HRS cell-specific retention of MHC class II and implicates CD4 T cells and additional MHC class I-independent immune effectors. Here, we utilize single-cell RNA sequencing and spatial analysis to define shared circulating and microenvironmental features of the immune response to PD-1 blockade in cHL.
View Article and Find Full Text PDFJ Transl Med
December 2024
Department of Urology, Xinjiang Medical University Affiliated Cancer Hospital, Urumqi, China.
Background: Immune checkpoint inhibitors (ICIs) are a cornerstone therapy for advanced renal cell carcinoma (RCC). However, significant rates of primary resistance hinder their efficacy, and the underlying mechanisms remain poorly understood. This study aims to unravel the tumor-immune interactions and signaling pathways driving primary resistance to ICIs in RCC.
View Article and Find Full Text PDFFish Shellfish Immunol
December 2024
Department of Marine Life Sciences & Center for Genomic Selection in Korean Aquaculture, Jeju National University, Jeju 63243, Republic of Korea; Marine Life Research Institute, Jeju National University, Jeju 63333, Republic of Korea. Electronic address:
Nucleoredoxin (NXN) is a prominent oxidoreductase enzyme, classified under the thioredoxin family, and plays a pivotal role in regulating cellular redox homeostasis. Although the functional characterization of NXN has been extensively studied in mammals, its role in fish remains relatively unexplored. In this study, the NXN gene from Planiliza haematocheilus (PhNXN) was molecularly and functionally characterized using in silico tools, expression analyses, and in vitro assays.
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