AI Article Synopsis
- * Researchers used single-cell RNA sequencing to find a specific microglial subgroup that responds similarly during different types of neurodegeneration, including both acute and chronic cases.
- * A unique temporary microglial population was discovered during the recovery phase, which could offer new opportunities for therapies aimed at enhancing brain healing.
Article Abstract
Microglia are brain immune cells that constantly survey their environment to maintain homeostasis. Enhanced microglial reactivity and proliferation are typical hallmarks of neurodegenerative diseases. Whether specific disease-linked microglial subsets exist during the entire course of neurodegeneration, including the recovery phase, is currently unclear. Taking a single-cell RNA-sequencing approach in a susceptibility gene-free model of nerve injury, we identified a microglial subpopulation that upon acute neurodegeneration shares a conserved gene regulatory profile compared to previously reported chronic and destructive neurodegeneration transgenic mouse models. Our data also revealed rapid shifts in gene regulation that defined microglial subsets at peak and resolution of neurodegeneration. Finally, our discovery of a unique transient microglial subpopulation at the onset of recovery may provide novel targets for modulating microglia-mediated restoration of brain health.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123921 | PMC |
| http://dx.doi.org/10.1186/s40478-018-0584-3 | DOI Listing |
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