Antiviral activity of multifunctional composite based on TiO-modified hydroxyapatite.

An antiviral activity of TiO-modified hydroxyapatite composite (HA/TiO) had been investigated. The HA/TiO composite (HA50:Ti50) was prepared by a solid state reaction method followed by calcination at 650 °C for 2 h. Phase formations and morphologies of the obtained HA/TiO composite powders were determined using XRD and SEM. XRD result confirmed that HA/TiO composite was successfully prepared. SEM revealed small crystals of anatase TiO embedded in larger HA crystals. A strong antiviral activity against H1N1 Influenza A Virus was observed at 0.5 mg/ml concentration of the composite under the UV irradiation for 60 min. It showed the highest rate of reducing virus titer approximately more than 2 log/h. Results obtained from this study indicated that HA/TiO composite could be a promising material to be used as antimicrobial filtration applications such as in face masks.