Self-assembled block copolymer [(BenzA)-b-(PCL)] micelles to orient randomly distributed AuNPs into hollow core-shell morphology and its role as payload for nanomedicines.

Synthesis and characterization of the di-block copolymer (di-BCP) of [(BenzA)-b-(PCL)] between benzyl alcohol (BenzA) and poly-ɛ-caprolactone (PCL) follow the development of micelles has been carried out. These developed [(BenzA)-b-(PCL)] based micelles are acting as an adjunct to assemble and arrange gold nanoparticles (AuNPs) in particular shape. Polymeric micelle driving randomly arranged AuNPs to form hollow core-shell (hCS) type morphology in a stringent assembler manner. The synthesis of [(BenzA)-b-(PCL)] has been performed through addition polymerization methods without using any surfactants and precursors. The average size of AuNPs is ~18 nm (in diameter). Interestingly, di-BCP based micelles formulation and their role in arranging AuNPs into hCS is a novel and unique approach to develop carrier capsules in biomedical field as well as drug delivery systems (DDSs). The average core size is ~44 nm with shell size of ~26 nm. However, [(BenzA)-b-(PCL)-(AuNPs)] based hCS capsules were used as payload for anticancer drug doxorubicin hydrochloride (DOX) for controlled release. Moreover, these [(BenzA)-b-(PCL)-(AuNPs)] based hCS are pH sensitive. It disintegrates at acidic pH (~5.3) and releases DOX molecules in a sustained manner. Furthermore, these [(BenzA)-b-(PCL)-(AuNPs)] based hCS are appended and evidenced as best carrier capsules for nano-medicines with enhanced loading efficacy (~74%) and dosage based prolonged release kinetics.