[This corrects the article DOI: 10.1371/journal.pone.0201135.].
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Bioinformatics
January 2025
Department of Computer Science, City University of Hong Kong, Hong Kong, China.
Motivation: Proteoforms are the different forms of a proteins generated from the genome with various sequence variations, splice isoforms, and post-translational modifications. Proteoforms regulate protein structures and functions. A single protein can have multiple proteoforms due to different modification sites.
View Article and Find Full Text PDFFront Immunol
January 2025
Department of Computer Science, University of Victoria, Victoria, BC, Canada.
Introduction: Accurate genotyping of Killer cell Immunoglobulin-like Receptor (KIR) genes plays a pivotal role in enhancing our understanding of innate immune responses, disease correlations, and the advancement of personalized medicine. However, due to the high variability of the KIR region and high level of sequence similarity among different KIR genes, the generic genotyping workflows are unable to accurately infer copy numbers and complete genotypes of individual KIR genes from next-generation sequencing data. Thus, specialized genotyping tools are needed to genotype this complex region.
View Article and Find Full Text PDFPhys Rev Lett
November 2024
Eastern Institute of Technology, Ningbo 315200, China.
Polymorphs commonly exist for various materials, enabling phase engineering for diverse material properties. While the crystal structures of different polymorphs can, in principle, be experimentally characterized, interpreting and understanding complex crystal structures can be very challenging. Using Ga_{2}O_{3} as a prototype, here we show that the crystal structure of γ-Ga_{2}O_{3} has long been misinterpreted from either theory or experiment.
View Article and Find Full Text PDFNeurobiol Dis
January 2025
Neurocenter, Department of Neurosurgery, Turku University Hospital and University of Turku, P.O. Box 52, FI-20521 Turku, Finland; Neuroscience Center, HiLIFE, University of Helsinki, P.O. Box 63, FI-00014 Helsinki, Finland; Department of Neurosurgery, Oulu University Hospital, Box 25, 90029, OYS, Finland.. Electronic address:
Lipidomic alterations have been associated with various neurological diseases. Examining temporal changes in serum lipidomic profiles, irrespective of injury type, reveals promising prognostic indicators. In this longitudinal prospective observational study, serum samples were collected early (46 ± 24 h) and late (142 ± 52 h) post-injury from 70 patients with ischemic stroke, aneurysmal subarachnoid hemorrhage, and traumatic brain injury that had outcomes dichotomized as favorable (modified Rankin Scores (mRS) 0-3) and unfavorable (mRS 4-6) three months post-injury.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
December 2024
SCES's Indira College of Pharmacy, New Mumbai Pune Highway, Tathawade, Pune, India.
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