AI Article Synopsis
- Virus infection in human cells was observed 3 hours after the virus invaded, using a viral vector that can replicate in specially modified cells.
- The study identified two main cellular responses during the viral invasion: the first occurs at 3 hours, potentially linked to changes in DNA composition.
- A second response, which happens around 9 hours later, appears to involve decreased protein concentration or changes in how phenylalanine is taken up into the nucleus.
Article Abstract
Virus infection of a human cell was determined only 3 h after invagination. We used viral vector Ad-CMV-control (AdC), which lacks the E1 gene coding for early polypeptide 1 (E1). AdC can replicate in human embryonic kidney 293 (HEK293) cells into which the E1 gene has been transfected. According to partial least-square regression discriminant analysis, it was assumed that two kinds of reaction take place in the cell during viral invasion. The first response of the cell was determined 3 h after the virus invasion, and the second one was determined ∼9 h later. The first one seems to be due to compositional changes in DNA. Analysis of large-scale datasets strongly indicated that the second reaction can be attributed to a reduction in protein concentration or uptake of phenylalanine into the nucleus.
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| http://dx.doi.org/10.1117/1.JBO.23.9.097001 | DOI Listing |
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