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Extracellular domains of CATSPERε are essential for CatSper assembly during development and activity modulation in sperm capacitation.
bioRxiv
November 2024
Department of Cellular and Molecular Physiology, Yale School of Medicine, CT.
Article Synopsis
- The CatSper channel is crucial for sperm fertility as it regulates calcium signaling necessary for sperm movement.
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Sperm-Specific CatSper is Not Conserved in All Vertebrates and May Not be the Only Progesterone-Responsive Ion Channel Present in Sperm.
J Membr Biol
August 2024
School of Biological Sciences, National Institute of Science Education and Research Bhubaneswar, P.O. Jatni, Khurda, 752050, Odisha, India.
Progesterone (P4) acts as a key conserved signalling molecule in vertebrate reproduction. P4 is especially important for mature sperm physiology and subsequent reproductive success. "CatSpermasome", a multi-unit molecular complex, has been suggested to be the main if not the only P4-responsive atypical Ca-ion channel present in mature sperm.
View Article and Find Full Text PDFTranscriptomic signature, bioactivity and safety of a non-hepatotoxic analgesic generating AM404 in the midbrain PAG region.
Sci Rep
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Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA, 70112, USA.
Safe and effective pain management is a critical healthcare and societal need. The potential for acute liver injury from paracetamol (ApAP) overdose; nephrotoxicity and gastrointestinal damage from chronic non-steroidal anti-inflammatory drug (NSAID) use; and opioids' addiction are unresolved challenges. We developed SRP-001, a non-opioid and non-hepatotoxic small molecule that, unlike ApAP, does not produce the hepatotoxic metabolite N-acetyl-p-benzoquinone-imine (NAPQI) and preserves hepatic tight junction integrity at high doses.
View Article and Find Full Text PDFDiltiazem HCl suppresses porcine reproductive and respiratory syndrome virus infection in susceptible cells and in swine.
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College of Agronomy, Liaocheng University, Liaocheng, China. Electronic address:
Porcine reproductive and respiratory syndrome virus (PRRSV) is a pathogen for swine, resulting in substantial economic losses to the swine industry. However, there has been little success in developing effective vaccines or drugs for PRRSV control. In the present study, we discovered that Diltiazem HCl, an inhibitor of L-type Ca channel, effectively suppresses PRRSV replication in MARC-145, PK-15 and PAM cells in dose-dependent manner.
View Article and Find Full Text PDFHigh-Performance Monolithic 3D Integrated Complementary Inverters Based on Monolayer n-MoS and p-WSe.
Small
April 2024
Department of Materials Science and Engineering, National Tsing-Hua University, Hsinchu, 30013, Taiwan.
Herein, the structure of integrated M3D inverters are successfully demonstrated where a chemical vapor deposition (CVD) synthesized monolayer WSe p-type nanosheet FET is vertically integrated on top of CVD synthesized monolayer MoS n-type film FET arrays (2.5 × 2.5 cm) by semiconductor industry techniques, such as transfer, e-beam evaporation (EBV), and plasma etching processes.
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