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Overcoming ammonia inhibition via biochar-assisted anaerobic co-digestion of thermally-treated thickened waste activated sludge and food waste.
J Environ Manage
December 2024
Chemical and Biochemical Engineering Department, University of Western Ontario, London, ON, N6A 5B9, Canada; Civil and Environmental Engineering Department, University of Western Ontario, London, ON, N6A 5B9, Canada. Electronic address:
The convergence of sustainability and climate change has catalyzed the pursuit of inventive strategies for waste management and sustainable energy production. Hereby, we explored the effect of coupling biochar addition and thermal pretreatment in anaerobic mono-digestion and co-digestion of thermally pretreated thickened waste activated sludge (PTWAS) with food waste (FW). Six semi-continuous lab-scale digesters were operated for 161 days at various organic loading rates (OLR of 2, 3, 4 and 8 kgCOD/m/day) with and without biochar (BC) addition.
View Article and Find Full Text PDFExplore the toxicological mechanism of 6PPD-Q on human health through a novel perspective: The interaction between lactate dehydrogenase and 6PPD-Q.
Int J Biol Macromol
December 2024
School of Chemistry and Chemical Engineering, Nanchang University, Nanchang 330031, Jiangxi, China. Electronic address:
N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone (6PPD-Q), an oxidative derivative of tire anti-degradant, has been linked to mortality in coho salmon (Oncorhynchus kisutch) and has exhibited potential human toxicity. Hence, exploring how 6PPD-Q interacts with biomacromolecules like enzymes is indispensable to assess its human toxicity and elucidate its mechanism of action. This investigation aims to explore the impact of 6PPD-Q on lactate dehydrogenase (LDH) through various methods.
View Article and Find Full Text PDFA crucial active site network of titratable residues guides catalysis and NAD binding in human succinic semialdehyde dehydrogenase.
Protein Sci
January 2025
Department of Neuroscience, Biomedicine and Movement Sciences, Section of Biochemistry, University of Verona, Verona, Italy.
Human succinic semialdehyde dehydrogenase is a mitochondrial enzyme fundamental in the neurotransmitter γ-aminobutyric acid catabolism. It catalyzes the NAD-dependent oxidative degradation of its derivative, succinic semialdehyde, to succinic acid. Mutations in its gene lead to an inherited neurometabolic rare disease, succinic semialdehyde dehydrogenase deficiency, characterized by mental and developmental delay.
View Article and Find Full Text PDFEducational Intervention on Awareness of Health-Damaging Behaviors in Educators.
Sports (Basel)
December 2024
Department of Humanities, Movement and Education Science, Niccolò Cusano University, 00166 Rome, Italy.
Doping prevention transcends elite sports, highlighting a broader societal challenge where performance enhancement is driven by pressures to increase strength, beauty, and status. This issue extends to adolescents and non-competitive sports participants, where self-optimization pressures are increasingly normalized. Research underscores the need for tailored educational interventions that go beyond punitive measures, fostering ethical decision-making and personal responsibility.
View Article and Find Full Text PDFMolecular regulatory effect of the ergot alkaloid methylergometrine on the α3β4 nicotinic acetylcholine receptor.
Biochem Biophys Res Commun
December 2024
Department of Biotechnology and Department of Integrative Food, Bioscience and Biotechnology (BK21 FOUR), Chonnam National University, Gwangju, 61186, South Korea. Electronic address:
Methylergometrine has widely been used pharmacologically to treat conditions such as pain, addiction, vasoconstriction, migraines, and Parkinson's disease. Despite its side effects, it is used as a therapeutic agent and research material for various diseases based on its natural potential; however, the regulatory effect of its interaction with the nicotinic acetylcholine receptor (nAChR) has not yet been investigated. The α3β4 nAChR is an ion channel essential for neurotransmission within the sympathetic, parasympathetic, and autonomic nervous systems.
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