Because all climate models exhibit biases, their use for assessing future climate change requires implicitly assuming or explicitly postulating that the biases are stationary or vary predictably. This hypothesis, however, has not been, and cannot be, tested directly. This work shows that under very large climate change the bias patterns of key climate variables exhibit a striking degree of stationarity. Using only correlation with a model's preindustrial bias pattern, a model's 4xCO bias pattern is objectively and correctly identified among a large model ensemble in almost all cases. This outcome would be exceedingly improbable if bias patterns were independent of climate state. A similar result is also found for bias patterns in two historical periods. This provides compelling and heretofore missing justification for using such models to quantify climate perturbation patterns and for selecting well-performing models for regional downscaling. Furthermore, it opens the way to extending bias corrections to perturbed states, substantially broadening the range of justified applications of climate models.
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http://dx.doi.org/10.1073/pnas.1807912115 | DOI Listing |
BMC Health Serv Res
January 2025
Amref Health Africa in Ethiopia, EPI Technical Assistant at West Gondar Zonal Health Department, SLL Project, COVID-19 Vaccine, Gondar, Ethiopia.
Background: Ethiopian healthcare relies heavily on Health Extension Workers (HEWs), who deliver essential services to communities nationwide. By analyzing existing research, the authors explore how prevalent job satisfaction is and what factors affect it. This comprehensive analysis aims to improve HEW satisfaction through targeted interventions, ultimately leading to a more effective healthcare workforce and better health outcomes in Ethiopia.
View Article and Find Full Text PDFClin Epigenetics
January 2025
Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Alcohol consumption is an important risk factor for multiple diseases. It is typically assessed via self-report, which is open to measurement error through recall bias. Instead, molecular data such as blood-based DNA methylation (DNAm) could be used to derive a more objective measure of alcohol consumption by incorporating information from cytosine-phosphate-guanine (CpG) sites known to be linked to the trait.
View Article and Find Full Text PDFCommun Biol
January 2025
Department of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA.
Human behavior is strongly influenced by anticipation, but the underlying neural mechanisms are poorly understood. We obtained intracranial electrocephalography (iEEG) measurements in neurosurgical patients as they performed a simple sensory-motor task with variable (short or long) foreperiod delays that affected anticipation of the cue to respond. Participants showed two forms of anticipatory response biases, distinguished by more premature false alarms (FAs) or faster response times (RTs) on long-delay trials.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Psychological Sciences, Rice University, 6100 Main St, Houston, TX, 77005, USA.
Retirement has been associated with cognitive decline beyond normal age-related decline. However, there are many individual differences in retirement that can influence cognition. Subclinical depressive symptoms are common in late life and are associated with general memory decline and a bias towards remembering negative events (i.
View Article and Find Full Text PDFSci Rep
January 2025
Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
The characteristics of data produced by omics technologies are pivotal, as they critically influence the feasibility and effectiveness of computational methods applied in downstream analyses, such as data harmonization and differential abundance analyses. Furthermore, variability in these data characteristics across datasets plays a crucial role, leading to diverging outcomes in benchmarking studies, which are essential for guiding the selection of appropriate analysis methods in all omics fields. Additionally, downstream analysis tools are often developed and applied within specific omics communities due to the presumed differences in data characteristics attributed to each omics technology.
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