AI Article Synopsis
- Codon usage bias (CUB) and mRNA structural stability are key factors that positively impact mRNA expression levels in yeast (Saccharomyces cerevisiae).
- Researchers examined how adjustments in CUB and mRNA stability affect expression levels using both natural and mutated mRNAs.
- They found that while CUB and stability promote higher expression in natural mRNAs, deviating from these natural conditions disrupts this balance, indicating that nature optimizes codon composition and structural stability for mRNA expression.
Article Abstract
Codon usage bias (CUB) and mRNA structural stability are important intrinsic features of mRNA that correlate positively with mRNA expression level. However, it remains unclear whether the mRNA expression level can be regulated by adjusting these two parameters, influencing the mRNAs' structure. Here we explored the influence of CUB and mRNA structural stability on mRNA expression levels in Saccharomyces cerevisiae, using both wild type and computationally mutated mRNAs. Although in wild type, both CUB and mRNA stability positively regulate the mRNA expression level, any deviation from natural situation breaks such equilibrium. The naturally occurring codon composition is responsible for optimizing the mRNA expression, and under such composition, the mRNA structure having highest stability is selected by nature.
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| http://dx.doi.org/10.1016/j.ygeno.2018.08.009 | DOI Listing |
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