AI Article Synopsis
- - The study looked at how a high-fat diet affects triacylglycerol (TG) levels in KK-A mice, specifically when they were given diosgenin or a diosgenin-containing Chinese yam (sanyaku).
- - Results showed that both fasting and post-meal TG levels were significantly lower in mice that consumed these supplements, with increased fat oxidation observed during the night.
- - Additionally, certain liver mRNA levels related to fat metabolism were upregulated, indicating that diosgenin and sanyaku could help improve TG levels and metabolism in a way that might be beneficial for humans on a similar diet.
Article Abstract
In this study, we examined the fasted and postprandial triacylglycerol (TG) levels in KK- A mice fed a high-fat diet (HFD) or a HFD containing either 500 ppm (0.05%) of diosgenin or 500 ppm (0.05%) of diosgenin-containing Chinese yam sanyaku. Oral fat tolerance tests revealed that, not only in the fasting state but also after loading of lipid emulsion, plasma levels of TG were significantly reduced in sanyaku- and diosgenin- fed mice. Levels of fat oxidation, especially in the dark phase (from 7 p.m. to 7 a.m.), were increased in the sanyaku and diosgenin groups. Moreover mRNA levels of lipoprotein lipase and peroxisome proliferator-activated receptor γ, coactivator 1α were moderately upregulated in the liver of sanyaku- and diosgenin-ingested mice. These results suggest that consecutive ingestion of diosgenin or diosgenin-containing sanyaku at the dose achievable in a human diet potentially ameliorates fasted and postprandial hypertriacylglycerolemia, which could be associated with the improvement of TG metabolism.
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| http://dx.doi.org/10.1021/acs.jafc.8b03040 | DOI Listing |
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