Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.26355/eurrev_201808_15695 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Ovine Mined from RNA-Seq: Identification, Expression Profile, Promotion of Preadipocyte Differentiation, Promoter Activity, and Its Polymorphisms Related to Phenotypic Traits.
Animals (Basel)
December 2024
College of Life Science and Engineering, Northwest Minzu University, Lanzhou 730030, China.
Tail fat is essential for sheep survival in extreme environments, yet its significance is often overlooked, leading to the decline of fat-tailed breeds. This study identified a novel lncRNA, (), through transcriptome sequencing, showing differential expression in the tail adipose tissues of Lanzhou Fat-Tailed (LFT) sheep and Tibetan (TS) sheep. Highly expressed in adipose tissues, inhibits preadipocyte proliferation and promotes 3T3-L1 differentiation, suggesting its role in regulating fat deposition.
View Article and Find Full Text PDFmiRNA-431-5p enriched in EVs derived from IFN-β stimulated MSCs potently inhibited ZIKV through CD95 downregulation.
Stem Cell Res Ther
November 2024
Department of Orthopedics, Northern Jiangsu People's Hospital, Clinical Teaching Hospital of Medical School, Nanjing University, Yangzhou, China.
Background: Zika virus (ZIKV) primarily spreads through mosquito bites and can lead to microcephaly in infants and Guillain-Barre syndrome in adults. It is noteworthy that ZIKV can persist in the semen of infected males for extended periods and can be sexually transmitted. Infection with ZIKV has severe pathological manifestations on the testicular tissues of male mice, resulting in reduced sperm motility and fertility.
View Article and Find Full Text PDFThe circular RNA circ_0001742 regulates colorectal carcinoma proliferation and migration via the MicroRNA-431-5p/ALG8 axis.
Heliyon
August 2024
Department of Gastrointestinal Surgery, Affiliated Tumor Hospital, Guangxi Medical University, Nanning, China.
Background: Accumulating studies have found that circular RNAs (circRNAs) have a regulatory effect in a variety of tumors. However, to date, the relationship between specific circRNAs and colorectal cancer (CRC) remains elusive.
Methods: An RNA-sequencing method based on different metastatic potential of CRC cell lines was applied to evaluate the circRNA expression profile.
MicroRNA-431-5p inhibits angiogenesis, lymphangiogenesis, and lymph node metastasis by affecting TGF-β1/SMAD2/3 signaling via ZEB1 in gastric cancer.
Mol Carcinog
July 2024
The Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Article Synopsis
- Lymphangiogenesis is linked to lymphatic metastasis and tumor immune tolerance in gastric cancer, but its mechanisms are not fully understood.
- The study found that miR-431-5p is significantly downregulated in gastric cancer tissues and plasma, with lower levels associated with increased lymph node metastasis and poor prognosis.
- By targeting ZEB1, miR-431-5p inhibits the TGF-β1/SMAD2/3 pathway, reducing the secretion of factors that promote angiogenesis and lymphangiogenesis, and shows promise as a therapeutic option, especially in combination with anti-PD1 treatment.
MiR-431 promotes cardiomyocyte proliferation by targeting FBXO32 expression.
J Gene Med
January 2024
Guizhou University Medical College, Guiyang, Guizhou, China.
Background: The induction of cardiomyocyte (CM) proliferation is a promising approach for cardiac regeneration following myocardial injury. MicroRNAs (miRNAs) have been reported to regulate CM proliferation. In particular, miR-431 expression decreases during cardiac development, according to Gene Expression Omnibus (GEO) microarray data.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!