Target induced reconstruction of DNAzymatic amplifier nanomachines in living cells for concurrent imaging and gene silencing.

Chem Commun (Camb)

Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China.

Published: September 2018

A novel DNAzymatic amplifier nanomachine that is reconstructed in response to an mRNA input has been developed to enable the functions of concurrent sensitive mRNA imaging and activatable gene therapy in living cells.

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Source
http://dx.doi.org/10.1039/c8cc05832fDOI Listing

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