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http://dx.doi.org/10.21037/gs.2018.03.08 | DOI Listing |
J Affect Disord
January 2025
Department of Neurology, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Anhui Province, Hefei 230022, China; Department of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China; Department of Psychology and Sleep Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China. Electronic address:
Background: Electroconvulsive therapy (ECT) is an effective treatment for patients with major depressive disorder (MDD), but the underlying neuromodulatory mechanisms remain largely unknown. Functional stability represents a newly developed method based on the dynamic functional connectivity framework. This study aimed to explore ECT-evoked changes in functional stability and their relationship with clinical outcomes.
View Article and Find Full Text PDFGen Physiol Biophys
January 2025
Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia.
Senescence, a crucial yet paradoxical phenomenon in cellular biology, acts as a barrier against cancer progression while simultaneously promoting aging and age-related pathologies. This duality underlines the importance of precise monitoring of senescence response, especially with regard to the proposed use of drugs selectively removing senescent cells. In particular, little is known about the role of senescence in neurons and in neurodegenerative diseases.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Wellcome Centre for Integrative Neuroimaging, Department of Experimental Psychology, University of Oxford, Oxford OX1 3TA, United Kingdom.
Daily life for humans and other animals requires switching between periods of threat- and reward-oriented behavior. We investigated neural activity associated with spontaneous switching, in a naturalistic task, between foraging for rewards and seeking information about potential threats with 7T fMRI in healthy humans. Switching was driven by estimates of likelihood of threat and reward.
View Article and Find Full Text PDFPain Ther
January 2025
Robert Wood Johnson University Hospital/Rutgers Medical School, New Brunswick, NJ, USA.
Introduction: Many interventional strategies are commonly used to treat chronic low back pain (CLBP), though few are specifically intended to target the distinct underlying pathomechanisms causing low back pain. Restorative neurostimulation has been suggested as a specific treatment for mechanical CLBP resulting from multifidus dysfunction. In this randomized controlled trial, we report outcomes from a cohort of patients with CLBP associated with multifidus dysfunction treated with restorative neurostimulation compared to those randomized to a control group receiving optimal medical management (OMM) over 1 year.
View Article and Find Full Text PDFACS Med Chem Lett
January 2025
Usona Institute, Fitchburg, Wisconsin 53711-5300, United States.
This Patent Highlight explores recent innovations in neuroscience and neurotechnology, particularly in brain monitoring and stimulation. It examines four essential patents: novel psychoplastogens for neuronal growth, techniques for transferring emotional states, and advanced systems for self-guided neural diagnostics and treatment. The discussion extends to deep brain stimulation (DBS) for motor and memory disorders, enhanced brain function monitoring through electroencephalography (EEG), and the role of artificial intelligence in personalizing treatment strategies.
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