AI Article Synopsis
- Intracerebral hemorrhage (ICH) is a serious brain condition that often leads to high rates of disability and death, primarily due to brain swelling and damage from released erythrocytes and their byproducts.
- Heme oxygenase-1 (HO-1) is an important enzyme activated quickly after brain injuries, playing a complex role in managing the effects of ICH through its metabolites.
- This review focuses on recent research about HO-1's effects after ICH, highlighting its potential neuroprotective benefits and impact on recovery outcomes.
Article Abstract
Intracerebral hemorrhage (ICH) is a fatal acute cerebrovascular disease, with a high morbidity and mortality. Following ICH, erythrocytes release heme and several of its metabolites, thereby contributing to brain edema and secondary brain damage. Heme oxygenase is the initial and rate-limiting enzyme of heme catabolism, and the expression of heme oxygenase-1 (HO-1) is rapidly induced following acute brain injury. As HO-1 exerts it effects via various metabolites, its role during ICH remains complex. Therefore, in-depth studies regarding the role of HO-1 in secondary brain damage following ICH may provide a theoretical basis for neuroprotective function after ICH. The present review aims to summarize recent key studies regarding the effects of HO-1 following ICH, as well as its influence on ICH prognosis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109777 | PMC |
| http://dx.doi.org/10.3389/fneur.2018.00682 | DOI Listing |
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