This paper seeks to extend prior research by exploring whether family structure transition is associated with an increase in early alcohol consumption and whether this association is mediated by; children's socio-emotional problems, providing information on whether the effects of the transition; differ according to the number of changes, the family's initial status, or the time of exposure. The; data have been drawn from the UK Millennium Cohort Study to explore associations framed with; a life-course approach. Our findings suggest that types of family transitions (such as distinguishing; parental exits from and parental entrances to the family) are more important than the number of; family changes during childhood. The results show that moving from a two-parent household to a single-parent household directly increased the probability of being a frequent alcohol consumer among early adolescent boys, whereas the indirect effect on girls was found via socio-emotional difficulties. Our findings also show an increase in socio-emotional and behavioural difficulties in boys due to the entrance of a step-parent only if the transition occurred in the earliest childhood. Indeed, a sensitivity analysis of the time to which the children were exposed to the transition to a new family structure showed stronger effects for those who experienced a family structure change in the early life course, consistent with the cumulative disadvantage process.
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http://dx.doi.org/10.1016/j.socscimed.2018.08.017 | DOI Listing |
J Interferon Cytokine Res
March 2025
Department of Microbiology, Seattle School of Medicine, University of Washington, Seattle, Washington, USA.
Alphaviruses (family Togaviridae) are a diverse group of positive-sense RNA (+ssRNA) viruses that are transmitted by arthropods and are the causative agent of several significant human and veterinary diseases. Interferon (IFN)-induced proteins with tetratricopeptide repeats (IFITs) are a family of RNA-binding IFN-stimulated genes (ISGs) that are highly upregulated following viral infection and have been identified as potential restrictors of alphaviruses. The mechanism by which IFIT1 restricts RNA viruses is dependent on self and non-self-discrimination of RNA, and alphaviruses evade this recognition via their 5' untranslated region (UTR).
View Article and Find Full Text PDFFront Plant Sci
February 2025
Biotechnology Research Institute, Shanghai Academy of Agricultural Sciences, Shanghai, China.
12-oxo-phytodienoic acid reductase (OPR) is one of the key enzymes in the octadecanoid pathway, and it controls the last step of jasmonic acid (JA) biosynthesis. Although multiple isoforms and functions of s have been identified in various plants, no genes have been identified, and their possible roles in grapevine development and defense mechanisms remain unknown. In this study, nine genes were identified from grapevine genome and classified into two subfamilies.
View Article and Find Full Text PDFFoods
February 2025
School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China.
Chaetoglobosin A (CheA), a typical structure of the cytochalasin family, exhibits outstanding efficacy against a variety of tumor cells and plant pathogens. However, its low yield and high production cost are major obstacles limiting its wide application. In order to increase CheA yield, an engineered strain was established by overexpressing , the gene encoding the MFS family's efflux pump, on chassis cells lacking , which have been shown to act as a negative regulator of CheA biosynthesis.
View Article and Find Full Text PDFMaterials (Basel)
February 2025
College of Geology and Environment, Xi'an University of Science and Technology, Xi'an 710054, China.
This study focuses on the preparation of mesophase pitch via the thermal polycondensation of heavy components from low-temperature coal tar. By altering the coal tar composition through distillation, we investigated the impact of various coal tar components and reaction conditions on the properties of the resulting mesophase pitch. Techniques such as infrared spectroscopy, nuclear magnetic resonance, optical structure analysis, and family-component analysis were employed to analyze both the coal tar and mesophase pitch.
View Article and Find Full Text PDFHealthcare (Basel)
February 2025
Cranston Ridge Medical Clinic, Calgary, AB T3M 3A9, Canada.
There exist several interconnected issues that hinder the development of family medicine in Commonwealth realms such as the United Kingdom, Canada, New Zealand, and Australia. These issues affect both the medical and nursing professions. Family physicians, in most countries including the United Kingdom, are not considered "specialists" and are called "general practitioners" instead.
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