A water soluble Nostoc sphaeroids kütz polysaccharide (NSKP) was extracted and purified by precipitating hot-water extract from Nostoc sphaeroids kütz with 40% (v/v) ethanol. The yield was 40.10% (w/w), and weight average molecular weight (M) was determined as 1.31 × 10 g/mol. Cell culture study showed that NSKP could stimulate the NO release from RAW264.7 macrophages. The ρ value (R/R) of NSKP was calculated as 1.50, indicating flexible random coils conformation of NSKP in aqueous solution. According to methylation analysis, and 1D & 2D NMR spectra, the molecular structure of polysaccharide NSKP was deduced as below.
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In this study, we investigated the effects of Kütz polysaccharide (NSKP) on renal fibrosis in high-fat mice. ApoE male mice were randomly divided into four groups: control (Cont) group, high-fat diet (HFD) group, HFD+0.4 g/kg BW NSKP, and HFD+0.
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Gut microbiota is the collection of microbes that lives in the host. Glycan is the major factor to shape the composition of microbial community. Nostoc sphaeroids Kütz (NSK) has been used as food and medicine for thousands of years in Asian countries while the bioactivity on gut microbiota is unclear till now.
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Hunan Yandi Bioengineering Co. Ltd. Zhuzhou, Hunan Province 412000, China. Electronic address:
A water soluble Nostoc sphaeroids kütz polysaccharide (NSKP) was extracted and purified by precipitating hot-water extract from Nostoc sphaeroids kütz with 40% (v/v) ethanol. The yield was 40.10% (w/w), and weight average molecular weight (M) was determined as 1.
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