AI Article Synopsis
- Recent research has illuminated the transcriptional networks that determine iNKT cell lineage and their functional subsets.
- Despite these advancements, the role of epigenetic factors in regulating gene expression and lineage decisions in iNKT cells is still not well understood.
- This discussion highlights recent findings on the epigenetic regulation of iNKT cell development, focusing specifically on DNA modifications and the TET family of DNA demethylases.
Article Abstract
During the last years, intensive research has shed light in the transcriptional networks that shape the invariant NKT (iNKT) cell lineage and guide the choices towards functionally distinct iNKT cell subsets (Constantinides and Bendelac, 2013; Engel and Kronenberg, 2014; Gapin, 2016; Kim et al., 2015). However, the epigenetic players that regulate gene expression and orchestrate the iNKT cell lineage choices remain poorly understood. Here, we summarize recent advances in our understanding of epigenetic regulation of iNKT cell development and lineage choice. Particular emphasis is placed on DNA modifications and the Ten Eleven Translocation (TET) family of DNA demethylases.
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| http://dx.doi.org/10.1016/j.molimm.2018.08.020 | DOI Listing |
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