Performance analysis of different classification algorithms using different feature selection methods on Parkinson's disease detection.

Background: In diagnosis of neurodegenerative diseases, the three-dimensional magnetic resonance imaging (3D-MRI) has been heavily researched. Parkinson's disease (PD) is one of the most common neurodegenerative disorders.

New Method: The performances of five different classification approaches using five different attribute rankings each followed with an adaptive Fisher stopping criteria feature selection (FS) method are evaluated. To improve the performance of PD detection, a source fusion technique which combines the gray matter (GM) and white (WM) tissue maps and a decision fusion technique which combines the outputs of all classifiers using the correlation-based feature selection (CFS) method by majority voting are used.

Results: Among the five FS methods, the CFS provides the highest results for all five classification algorithms and the SVM provides the best classification performances for all five different FS methods. The classification accuracy of 77.50% and 81.25% are obtained for the GM and WM tissues, respectively. However, the fusion of GM and WM datasets improves the classification accuracy of the proposed methodology up to 95.00%.

Comparison With Existing Methods: An f-contrast is used to generate 3D masks for GM and WM datasets and a fusion technique, combining the GM and WM datasets is used. Several classification algorithms using several FS methods are performed and a decision fusion technique is used.

Conclusions: Using the combination of the 3D masked GM and WM tissue maps and the fusion of the outputs of multiple classifiers with CFS method gives the classification accuracy of 95.00%.