At the end of the 18th Century, the history of immunology began in Mexico, with Francisco Xavier Balmis, who initiated the process of vaccination against smallpox. By doing this, he established the bases for research and clinical practice in this field of medicine. Among the pioneers of immunology in Mexico stand out Eduardo Licega, Maximiliano Ruiz Castañeda and Mario Salazar Mallén. This last one founded the first allergy laboratory located in the Hospital General de Mexico, becoming the first one of its nature in the entire nation as well as being recognized by Universidad Nacional Autónoma de México (UNAM) as the first course of allergy. The Unique Plan of Medical Specializations (PUEM it's the acronym in Spanish) is a curricular plan organized in a functional conceptual construction, destined to conduct medical educational actions and designed by Faculty of Medicine UNAM, health institutes and the Mexican counsels of specialists; having as the main purpose that medical residents acquire knowledge, ability, skills, and ethical values to practice medicine with quality and efficiency. The specialty of Allergy and Clinic Immunology is part of PUEM since 1994 for adult patients and since 1998 in pediatrics. At the present it's being held in 8 different institutions of health conformed by six courses for adult patients and two for pediatric ones. The UNAM evaluates the quality of the specialty courses through diverse processes, all coordinated by the Postgraduate Department from the Faculty of Medicine, through the coordination of academic subcommittees who's also helped by the members of the Academic Subcommittees of Allergy and Clinic Immunology with the objective of guaranteeing quality in the formation of human resources.
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http://dx.doi.org/10.29262/ram.v65i3.535 | DOI Listing |
Nat Commun
December 2024
Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Antibody-mediated protection against pathogens is crucial to a healthy life. However, the recent SARS-CoV-2 pandemic has shown that pre-existing comorbid conditions including kidney disease account for compromised humoral immunity to infections. Individuals with kidney disease are not only susceptible to infections but also exhibit poor vaccine-induced antibody response.
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December 2024
Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
The mechanism(s) underlying gut microbial metabolite (GMM) contribution towards alcohol-mediated cardiovascular disease (CVD) is unknown. Herein we observe elevation in circulating phenylacetylglutamine (PAGln), a known CVD-associated GMM, in individuals living with alcohol use disorder. In a male murine binge-on-chronic alcohol model, we confirm gut microbial reorganization, elevation in PAGln levels, and the presence of cardiovascular pathophysiology.
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December 2024
Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
Parainfluenza virus 3 (PIV3) infection poses a substantial risk to vulnerable groups including infants, the elderly, and immunocompromised individuals, and lacks effective treatments or vaccines. This study focuses on targeting the hemagglutinin-neuraminidase (HN) protein, a structural glycoprotein of PIV3 critical for viral infection and egress. With the objective of targeting these activities of HN, we identified eight neutralizing human monoclonal antibodies (mAbs) with potent effects on viral neutralization, cell-cell fusion inhibition, and complement deposition.
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December 2024
Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.
Immune checkpoint inhibitors (ICI) represent new anticancer agents and have been used worldwide. However, ICI can potentially induce life-threatening severe cutaneous adverse reaction (SCAR), such as Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), hindering continuous ICI therapy. We examine 6 cohorts including 25 ICI-induced SJS/TEN patients and conduct single-cell RNA sequencing (scRNA-seq) analysis, which shows overexpression of macrophage-derived CXCL10 that recruits CXCR3 cytotoxic T lymphocytes (CTL) in blister cells from ICI-SJS/TEN skin lesions.
View Article and Find Full Text PDFElife
December 2024
Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
Psoriasis is a multifactorial disorder mediated by IL-17-producing T cells, involving immune cells and skin-constituting cells. Semaphorin 4A (Sema4A), an immune semaphorin, is known to take part in T helper type 1/17 differentiation and activation. However, Sema4A is also crucial for maintaining peripheral tissue homeostasis and its involvement in skin remains unknown.
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