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The centennial of E.B. Wilson's The Cell in Development and Heredity.

Mol Biol Cell

December 2024

Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA 01605.

Article Synopsis
  • The article reviews the third edition of E.B. Wilson's influential book "The Cell in Development and Heredity," highlighting its unique characteristics and historical context.
  • Colleagues provide personal insights on how Wilson's work has impacted their understanding of cell biology, emphasizing its lasting significance nearly 100 years after its initial publication.
  • The piece celebrates Wilson's contributions as a pivotal figure in American cell biology, showcasing the volume's continued relevance in the field.
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Barriers and Enablers in Prehospital Pediatric Analgesia.

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December 2024

Department of Emergency Medicine, Alpert Medical School, Brown University, Providence, Rhode Island.

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  • Children represent a small percentage of EMS transports but often experience under-treatment of pain; this study examines factors influencing EMS clinicians' ability to provide effective prehospital pain management for pediatric patients.
  • Key enablers identified include longer transport times, the need to stabilize patients, and clinician familiarity with intranasal fentanyl, while barriers include concerns over patient stability, caregiver discomfort with pain medications, and limited pediatric experience among EMS staff.
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Despite nursing's stated mandate of health equity and social justice, concrete steps to address racism and anti-Black racism in the profession and nursing education remain mainly non-significant and are often seen as performative. It is crucial to implement tangible measures to dismantle racism and anti-Black racism in nursing education to address racial health disparities. Throughout history, nursing education has been shaped by colonial and Eurocentric ideologies, leading to the silencing and erasure of the knowledge, culture, perspectives, and ways of knowing of Black and other racialized communities.

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Classifying compounds as prebiotics - scientific perspectives and recommendations.

Nat Rev Gastroenterol Hepatol

January 2025

International Scientific Association for Probiotics and Prebiotics, Centennial, CO, USA.

Microbiomes provide key contributions to health and potentially important therapeutic targets. Conceived nearly 30 years ago, the prebiotic concept posits that targeted modulation of host microbial communities through the provision of selectively utilized growth substrates provides an effective approach to improving health. Although the basic tenets of this concept remain the same, it is timely to address certain challenges pertaining to prebiotics, including establishing that prebiotic-induced microbiota modulation causes the health outcome, determining which members within a complex microbial community directly utilize specific substrates in vivo and when those microbial effects sufficiently satisfy selectivity requirements, and clarification of the scientific principles on which the term 'prebiotic' is predicated to inspire proper use.

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