AI Article Synopsis
- A study investigated the genotoxic effects of the organophosphate quinalphos on freshwater fish over 30 days using varying sub-lethal doses.
- Measurements included biochemical characteristics (protein and lipid levels), as well as nuclear and morphological abnormalities in fish erythrocytes (red blood cells) taken before and after treatment.
- Results showed a significant decrease in protein and lipid levels and an increase in nuclear and morphological abnormalities, supporting the use of these parameters to assess the genotoxicity of organophosphates.
Article Abstract
An study was carried out on the freshwater fish to evaluate the genotoxic effects of the organophosphate quinalphos. The fish were exposed to sub-lethal doses of quinalphos (0%, 10%, 25%, and 50% of LC) for a period of 30 days. Analysis of biochemical characteristics (protein and lipid contents of different organs), nuclear abnormalities of erythrocytes (NAE) and morphological abnormalities of erythrocytes (MAE) were performed on peripheral erythrocytes sampled at post-treatment intervals of 0 and 30 days. The biochemical results revealed a significant dose-dependent decline in protein and lipid contents and increase in the frequencies of NAE as well as MAE. Our findings also confirmed that the morphological deformations of erythrocytes in addition to NAE on fish erythrocytes are effective tools in determining the potential genotoxicity of organophosphates.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107646 | PMC |
| http://dx.doi.org/10.1515/intox-2017-0016 | DOI Listing |
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