AI Article Synopsis
- - The study investigates how the diverse roles of neurons rely on the transport of proteins to their proper locations, focusing on presynaptic zones crucial for neurotransmission.
- - Researchers used live imaging techniques in Drosophila larvae and mouse neurons to show that specific vesicles help transport synaptic proteins to presynaptic areas, and their loss affects neurotransmission negatively.
- - Findings highlight the significance of a lysosomal kinesin adaptor called Arl8, which, when lost, causes vesicle accumulation in cell bodies and presynaptic depletion, while its overexpression enhances synaptic function.
Article Abstract
Nervous system function relies on the polarized architecture of neurons, established by directional transport of pre- and postsynaptic cargoes. While delivery of postsynaptic components depends on the secretory pathway, the identity of the membrane compartment(s) supplying presynaptic active zone (AZ) and synaptic vesicle (SV) proteins is unclear. Live imaging in Drosophila larvae and mouse hippocampal neurons provides evidence that presynaptic biogenesis depends on axonal co-transport of SV and AZ proteins in presynaptic lysosome-related vesicles (PLVs). Loss of the lysosomal kinesin adaptor Arl8 results in the accumulation of SV- and AZ-protein-containing vesicles in neuronal cell bodies and a corresponding depletion of SV and AZ components from presynaptic sites, leading to impaired neurotransmission. Conversely, presynaptic function is facilitated upon overexpression of Arl8. Our data reveal an unexpected function for a lysosome-related organelle as an important building block for presynaptic biogenesis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.neuron.2018.08.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!