AI Article Synopsis
- - Individuals with schizophrenia who carry a specific genetic variant (rs2067477) in the M1 receptor gene show poorer performance on cognitive tests and reduced brain structure in certain areas.
- - A study was conducted with 176 patients to see if this genetic variation affected brain thickness and surface area, but no significant differences were found.
- - The researchers suggest future studies should look at related genetic variations near rs2067477 to better understand their impact on brain structure.
Article Abstract
Individuals with schizophrenia who are homozygous at the c.267C>A single nucleotide polymorphism (rs2067477) within the cholinergic muscarinic M1 receptor gene have been reported to perform less well on the Wisconsin Card Sorting Test and demonstrate reduced grey matter volume in the right precentral gyrus. We investigated if rs2067477 genotype variation influenced cortical thickness and cortical surface area in a sample of 176 schizophrenia/schizoaffective disorder patients using FreeSurfer. We were unable to detect any significant changes to either surface-based measure of brain structure across genotype. Future studies should expand the focus and include SNPs that are in linkage disequilibrium with rs2067477.
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| http://dx.doi.org/10.1016/j.pscychresns.2018.08.014 | DOI Listing |
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