AI Article Synopsis
- PSA is a crucial biomarker used for diagnosing and managing prostate cancer, particularly in tracking its progression to more advanced stages.
- The review discusses how PSA contributes to cancer progression through its serine protease activity, interactions with cellular receptors, and its ability to suppress immune responses.
- It also highlights important issues that need further investigation in relation to PSA's role in prostate cancer.
Article Abstract
Prostate-specific antigen (PSA) is a biomarker for the diagnosis and management of prostate cancer and involved in the development of prostate cancer and/or its progression from the localized to the metastatic stage. This review presents an overview of the roles of PSA in promoting the progression and metastasis of human prostate cancer and its underlying mechanisms, including its serine protease activity, interaction with the cellular membrane receptor, and suppression of specific immune responsiveness, and also points out some of the key problems to be solved.
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