Research in driver mental fatigue is motivated by the fact that errors made by drivers often have life-threatening consequences. This paper proposes a new modular design approach for the early detection of driver fatigue system taking into account optimisation of system performance using particle swarm optimisation (PSO). The proposed system is designed and implemented using an existing dataset that was simultaneously collected from participants and vehicles in a naturalistic environment. Four types of data are considered as fatigue-related metrics including: vehicle acceleration, vehicle rotation pattern, driver's head position and driver's head rotation. The driver's blink rate data is used in this work as a proxy for ground truth for the classification algorithm. The collected data elements are initially fed to input modules represented by ternary neural network classifiers that estimates alertness. A Bayesian algorithm with PSO is then used to combine and optimise detection performance based on the number of existing input modules as well as their output states. Performance of the developed fatigue-detection system is assessed experimentally with a small data samples of driver trips. The obtained results are found in agreement with the state-of-the-art in terms of accuracy (90.4%), sensitivity (92.6%) and specificity (90.7%). These results are achieved with significant design flexibility and robustness against partial loss of input data source(s). However, due to small sample size of dataset (N = 3), a larger dataset need to be tested with the same system framework to generalise the findings of this work.
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http://dx.doi.org/10.1016/j.aap.2018.08.012 | DOI Listing |
J Am Chem Soc
January 2025
Center for Sustainable Materials (SusMat), School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore.
Complex coacervation is a form of liquid-liquid phase separation, whereby two types of macromolecules, usually bearing opposite net charges, self-assemble into dense microdroplets driven by weak molecular interactions. Peptide-based coacervates have recently emerged as promising carriers to deliver large macromolecules (nucleic acids, proteins and complex thereof) inside cells. Thus, it is essential to understand their assembly/disassembly mechanisms at the molecular level in order to tune the thermodynamics of coacervates formation and the kinetics of cargo release upon entering the cell.
View Article and Find Full Text PDFGenomics Proteomics Bioinformatics
January 2025
Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Research Unit of Hematologic Malignancies Genomics and Translational Research of Chinese Academy of Medical Sciences, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) techniques hold great value in evaluating the heterogeneity and spatial characteristics of hematopoietic cells within tissues. These two techniques are highly complementary, with scRNA-seq offering single-cell resolution and ST retaining spatial information. However, there is an urgent demand for well-organized and user-friendly toolkits capable of handling single-cell and spatial information.
View Article and Find Full Text PDFNat Commun
January 2025
Department of Bioengineering, School of Engineering & Applied Science, University of Pennsylvania, Philadelphia, PA, 19104, USA.
From sequences of discrete events, humans build mental models of their world. Referred to as graph learning, the process produces a model encoding the graph of event-to-event transition probabilities. Recent evidence suggests that some networks are easier to learn than others, but the neural underpinnings of this effect remain unknown.
View Article and Find Full Text PDFMed Phys
January 2025
Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland.
Background: Total-body (TB) Positron Emission Tomography (PET) is one of the most promising medical diagnostics modalities, opening new perspectives for personalized medicine, low-dose imaging, multi-organ dynamic imaging or kinetic modeling. The high sensitivity provided by total-body technology can be advantageous for novel tomography methods like positronium imaging, demanding the registration of triple coincidences. Currently, state-of-the-art PET scanners use inorganic scintillators.
View Article and Find Full Text PDFBiomimetics (Basel)
December 2024
School of Information Engineering, Quanzhou Ocean Institute, Quanzhou 362700, China.
This study designs and develops a wearable exoskeleton piano assistance system for individuals recovering from neurological injuries, aiming to help users regain the ability to perform complex tasks such as playing the piano. While soft robotic exoskeletons have proven effective in rehabilitation therapy and daily activity assistance, challenges remain in performing highly dexterous tasks due to structural complexity and insufficient motion accuracy. To address these issues, we developed a modular division method based on multi-domain mapping and a top-down process model.
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