AI Article Synopsis
- Aging significantly increases the risk of developing cardiovascular diseases, making it crucial to understand how cellular aging can be targeted for therapy.
- Nrf2, a transcription factor linked to lifespan in rodents, plays a complex role in cardiovascular health, influencing the expression of protective genes against oxidative stress and cellular aging.
- The relationship between Nrf2 activity and vascular diseases varies by cell type, with its presence potentially offering protection in some cases while being detrimental in conditions like atherosclerosis, prompting the need for further research.
Article Abstract
Aging is the most critical risk factor for the development of cardiovascular diseases and their complications. Therefore, the fine-tuning of cellular response to getting older is an essential target for prospective therapies in cardiovascular medicine. One of the most promising targets might be the transcription factor Nrf2, which drives the expression of cytoprotective and antioxidative genes. Importantly, Nrf2 expression correlates with potential lifespan in rodents. However, the effect of Nrf2 activity in vascular diseases might be ambiguous and strongly depend on the cell type. On the one hand, the Nrf2 activity may protect cells from oxidative stress and senescence, on the other hand, total lack of Nrf2 is protective against atherosclerosis development. Therefore, this review aims to discuss the current knowledge on the role played by the transcription factor Nrf2 in cardiovascular diseases and its potential effects on aging.
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| http://dx.doi.org/10.1016/j.vph.2018.08.009 | DOI Listing |
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