Coxsackievirus A16 (CV-A16) commonly causes mild symptoms, but severe diseases, such as aseptic meningitis, encephalitis, and even fatal cases, have been reported. Thirteen CV-A16 strains were isolated from patients with severe hand, foot, and mouth disease in Yunnan, Southwest China, from 2009 to 2015. Subgenotype B1a and B1b of CV-A16 were predominantly circulating the region with B1b the predominant strain in recent years. The mean rate of nucleotide substitution based on the VP1 gene sequence was 4.545 × 10 substitution per site per year from 2009 to 2015. These results may help in understanding the genetic diversity of CV-A16 and develop a CV-A16 vaccine.
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Article Synopsis
- * The infection generally peaks in July, with children in kindergartens and scattered children making up the majority of cases (44.6% and 42.2%, respectively).
- * The study also included phylogenetic analysis of the enterovirus CVA16, revealing variations in the B1 sub-genogroup over the years, which could influence future prevention and control strategies.
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