Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor agonist, tricyclic antidepressant amitriptyline, significantly inhibits glutoxim- and molixan-induced Ca-responses in rat peritoneal macrophages. The results suggest possible involvement of sigma-1 receptors in the signaling cascade induced by glutoxim or molixan and leading to intracellular Ca concentration increase in macrophages.
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Sigma-1 Receptor Ligands Chlorpromazine and Trifluoperazine Attenuate Ca Responses in Rat Peritoneal Macrophages.
Cell tissue biol
May 2022
Department of Biophysics, St. Petersburg State University, 199034 St. Petersburg, Russia.
Sigma-1 receptors are ubiquitous multifunctional ligand-regulated molecular chaperones in the endoplasmic reticulum membrane with a unique history, structure, and pharmacological profile. Sigma-1 receptors bind ligands of different chemical structure and pharmacological action and modulate a wide range of cellular processes in health and disease, including Ca signaling. To elucidate the involvement of sigma-1 receptors in the processes of Ca signaling in macrophages we studied the effect of sigma-1 receptor ligands, phenothiazine neuroleptics chlorpromazine and trifluoperazine, on Ca responses induced by inhibitors of endoplasmic Ca-ATPases thapsigargin and cyclopiazonic acid, as well as by disulfide-containing immunomodulators Glutoxim and Molixan in rat peritoneal macrophages.
View Article and Find Full Text PDFNeuroleptic Chlorpromazine Modulates Ca Responses in Macrophages.
Dokl Biochem Biophys
January 2020
St. Petersburg State University, St. Petersburg, Russia.
Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor antagonist neuroleptic chlorpromazine significantly inhibits glutoxim- and molixan-induced Ca responses and Ca responses induced by endoplasmic reticulum Са-ATPase inhibitors thapsigargin and cyclopiazonic acid in rat peritoneal macrophages. The results suggest the involvement of sigma-1 receptors in the signaling cascade induced by glutoxim or molixan and leading to intracellular Ca concentration increase and in the regulation of store-dependent Ca entry in macrophages.
View Article and Find Full Text PDFAmitriptyline Attenuates Ca Responses Induced by Glutoxim and Molixan in Macrophages.
Dokl Biochem Biophys
July 2018
St. Petersburg State University, St. Petersburg, 199034, Russia.
Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor agonist, tricyclic antidepressant amitriptyline, significantly inhibits glutoxim- and molixan-induced Ca-responses in rat peritoneal macrophages. The results suggest possible involvement of sigma-1 receptors in the signaling cascade induced by glutoxim or molixan and leading to intracellular Ca concentration increase in macrophages.
View Article and Find Full Text PDFThe effects of various combinations of pharmacological agents on parameters characterizing red blood cell (RBC) membrane proteins and lipids have been investigated in RBC isolated from Wistar male rats with acute destructive pancreatitis induced under conditions of forced alcoholization for 60 days. Administration of a combination of Hepon, Hypoxenum, and Phosphogliv normalized 22.5% of parameters altered change during development of acute destructive pancreatitis under conditions of chronic alcoholization of parameters, corrected towards normal values 42.
View Article and Find Full Text PDFSigma-1 receptor antagonist haloperidol attenuates Ca responses induced by glutoxim and molixan in macrophages.
Dokl Biochem Biophys
January 2017
St. Petersburg State University, Universitetskaya nab. 7/9, St. Petersburg, 199034, Russia.
Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor antagonist, antipsychotic haloperidol, significantly inhibits glutoxim- and molixan-induced Ca-response in peritoneal macrophages. These results indicate possible involvement of sigma-1 receptors in the signal cascade induced by glutoxim or molixan and leading to intracellular Ca concentration increase in macrophages.
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