AI Article Synopsis
- Therapeutic drug delivery systems using polymers are becoming increasingly important due to their lower toxicity.
- Chitosan, a biodegradable polymer, is highlighted in recent research for its potential in drug delivery, especially as a chitosan derivative combined with folic acid and zinc.
- Multiple analytical techniques confirmed that the new ZnS/Chitosan-Folic acid derivative differs significantly from pure chitosan and falls within the nano-size range with an average particle size of 463.67 ± 5.76 nm.
Article Abstract
Therapeutic drug delivery systems using polymeric materials is an emerging field of research. However, the use of certain polymers has gained much-needed attention by the researchers due to their low toxic nature. In recent years, chitosan has gained popularity as a potential biodegradable polymer that can be used as a component in drug delivery systems. In this study, we synthesized a chitosan derivative that is composed of both folic acid and zinc and may serve as a viable component of a drug delivery system. The results of Fourier Transform Infrared Spectroscopy (FTIR), solid-state C Nuclear Magnetic Resonance Spectroscopy (NMR) and UV-visible Spectroscopy demonstrated a substantial difference between chitosan and ZnS/Chitosan-Folic acid derivative. The results were also confirmed using Thermogravimetric Analysis (TGA) and Scanning Electron Microscopy/Energy Dispersive X-ray Spectroscopy (SEM-EDS) techniques. The average particle size of the ZnS/Chitosan-Folic acid system was measured to be 463.67 ± 5.76 nm, showing that the product is within the nano-size range.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113674 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2018.e00737 | DOI Listing |
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