Realization of the first sub-shot-noise wide field microscope.

Recently, several proof of principle experiments have demonstrated the advantages of quantum technologies over classical schemes. The present challenge is to surpass the limits of proof of principle demonstrations to approach real applications. This letter presents such an achievement in the field of quantum enhanced imaging. In particular, we describe the realization of a sub-shot-noise wide field microscope based on spatially multi-mode non-classical photon number correlations in twin beams. The microscope produces realtime images of 8000 pixels at full resolution, for a 500 μm field of view, with noise reduced to 80% of the shot noise level (for each pixel), which is suitable for absorption imaging of complex structures. By fast post-elaboration, specifically applying a quantum enhanced median filter, the noise can be further reduced (to <30% of the shot noise level) by setting a trade-off with the resolution, thus achieving the best sensitivity per incident photon reported in absorption microscopy.