Objectives: Exposure to life stresses can lead to diminution in the capacity of stress response systems to mount a robust response to new challenges, with blunting of dynamic range-the spread between maximal attainable and minimal resting levels. We investigate the association between early-life adversity and the dynamic range of adult diurnal cortisol secretion.
Method: In 35- to 86-year-old adults, cortisol assayed from 16 saliva samples over 4 consecutive days was used to compute diurnal dynamic range and area under the curve (AUC). Economic adversity in childhood was indexed by recalled parental education, family welfare dependence, and perceived financial status; and childhood social adversity by parental separation, death, and abuse.
Results: Adjusted for age, gender, and race/ethnicity, both childhood adversities were strongly associated with smaller adult cortisol diurnal dynamic range, but not with AUC. The association with cortisol dynamic range was explained by adult social and economic variables.
Discussion: Early-life adversity appears to leave a long-term imprint on cortisol secretion dynamics, reducing diurnal dynamic range without increasing total secretion. This points to the importance of examining the adaptation capacity of physiological systems when studying the impact of early-life and chronic stresses on adult health.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612015 | PMC |
| http://dx.doi.org/10.1093/geronb/gby097 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
"The Brain is…": A Survey of the Brain's Many Definitions.
Neuroinformatics
January 2025
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA, 90024, USA.
A reader of the peer-reviewed neuroscience literature will often encounter expressions like the following: 'the brain is a dynamic system', 'the brain is a complex network', or 'the brain is a highly metabolic organ'. These expressions attempt to define the essential functions and properties of the mammalian or human brain in a simple phrase or sentence, sometimes using metaphors or analogies. We sought to survey the most common phrases of the form 'the brain is…' in the biomedical literature to provide insights into current conceptualizations of the brain.
View Article and Find Full Text PDFHighly Luminescent Nitrogen Doped Carbon Quantum Dots for Mercury Ion Sensing with Antibacterial Activity.
J Fluoresc
January 2025
Department of Chemistry, The University of Burdwan, Golapbag, Burdwan, 713104, India.
Nitrogen doped Carbon Quantum Dots (NCQDs) have been synthesized using most economical and easiest hydrothermal process. Here, N-phenyl orthophenylenediamine and citric acid were utilised as a source of nitrogen and carbon for the preparation of NCQDs. The synthesized NCQDs were characterized using experimental techniques like UV - Vis absorption, FT-IR, transmission electron microscopy (TEM), X-ray Diffraction (XRD), EDX, dynamic light scattering (DLS), fluorimeter and time resolved fluorescence spectroscopy.
View Article and Find Full Text PDFInvestigation of Metal Tellurides As Cathode Materials for High-Energy Lithium-Tellurium Batteries.
ACS Appl Mater Interfaces
January 2025
Department of Energy Engineering, Hanyang University, Seoul 04763, Republic of Korea.
Lithium-tellurium (Li-Te) batteries are gaining attention as a promising next-generation energy storage system due to their superior electrical conductivity and high volumetric capacity compared to sulfur and selenium. Tellurium's unique properties, such as suitable redox potential, excellent conductivity, high volumetric capacity, and greatest stability, position it as a strong candidate for negative electrode materials. This study explores the potential of metal tellurides, specifically CuTe and FeTe monolayers, as effective tellurium host materials, leveraging their polar interactions with lithium polytellurides.
View Article and Find Full Text PDFA Cost-Effective Computational Strategy for the Electronic Layout Characterization of a Second Generation Light-Driven Molecular Rotary Motor in Solution.
J Comput Chem
January 2025
Scuola Superiore Meridionale, Napoli, Italy.
Light-driven molecular rotary motors are nanometric machines able to convert light into unidirectional motions. Several types of molecular motors have been developed to better respond to light stimuli, opening new avenues for developing smart materials ranging from nanomedicine to robotics. They have great importance in the scientific research across various disciplines, but a detailed comprehension of the underlying ultrafast photophysics immediately after photo-excitation, that is, Franck-Condon region characterization, is not fully achieved yet.
View Article and Find Full Text PDFComparative Evaluation of Treatment Outcomes of Revision Anterior Cruciate Ligament Reconstruction Using Allograft and Semitendinosus Autograft.
J Clin Med
December 2024
Department of Orthopedics, Traumatology and Hand Surgery, Faculty of Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland.
The number of revision anterior cruciate ligament reconstruction (RACLR) procedures is increasing in proportion to the increase in the number of anterior cruciate ligament reconstruction (ACLR) procedures. Although approximately 50-75% of these procedures can be performed in a single-stage procedure, not all of them can. The choice of graft may influence the results of RACLR.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!