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Efficacy and tolerability of celastrol and edaravone in the multiple-hit rat model of infantile spasms.
Epilepsy Behav
January 2025
Albert Einstein College of Medicine, Saul R. Korey Department of Neurology, Laboratory of Developmental Epilepsy, Albert Bronx, NY, USA; Isabelle Rapin Division of Child Neurology, Albert Einstein College of Medicine, Bronx, NY, USA; Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address:
Objective: To test whether anti-inflammatory and antioxidant drugs that inhibit the nuclear factor kappa light chain enhancer of activated B cells (NF-kB), celastrol and edaravone, suppress spasms and improve developmental outcomes in the multiple-hit rat model of refractory infantile spasms (IS) due to structural lesions.
Methods: Postnatal day 3 (PN3) Sprague-Dawley rats were treated according to the multiple-hit IS model protocol. Using a randomized, blinded, vehicle-controlled, dose- and time-response study design, we tested the effects of single celastrol [1, 2, or 4 mg/kg intraperitoneally (i.
Advancing understanding of autoimmune disease-related interstitial lung disease (AD-ILD): A global perspective on research focus and future directions.
Autoimmun Rev
January 2025
Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China; Lung Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China; West China Clinical Medical College, Sichuan University, Chengdu, Sichuan 610041,China. Electronic address:
Article Synopsis
- Interstitial lung disease (ILD), particularly autoimmune disease-associated ILD (AD-ILD), is a serious complication associated with autoimmune diseases that can lead to significant health risks and poor patient outcomes, yet research on it has been limited in terms of bibliometric studies.
- This study analyzed 6,456 publications from 1980 to 2024 using bibliometric tools to identify global research trends, with a focus on the contributions from various countries, institutions, and researchers in the field.
- Findings revealed a surge in research since 2018, primarily led by the United States and Mayo Clinic, and emphasized key areas for future investigation such as diagnostic tools, biomarkers, and personalized therapies for AD-ILD.
Flares of Systemic Autoimmune Rheumatic Disease Following Coronavirus Disease 2019 Vaccination: A Narrative Review.
Rheum Dis Clin North Am
February 2025
Division of Rheumatology, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA; Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
This narrative review summarizes current evidence on the risk of systemic autoimmune rheumatic disease (SARD) flare following coronavirus disease 2019 vaccination. The authors detail key studies in the literature employing diverse methodologies, including cross-sectional surveys, prospective and retrospective cohorts, case-crossover designs, self-controlled case series, and systematic reviews. Data are reassuring, suggesting that vaccination is unlikely to increase the risk of flares across a range of SARD.
View Article and Find Full Text PDFPharmacokinetics and brain uptake of sodium selenate and selenium in naïve rats and a lateral fluid percussion injury rat model.
Pharmacol Res Perspect
December 2024
College of Pharmacy, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA.
Article Synopsis
- - Post-traumatic epilepsy (PTE) is a serious complication following traumatic brain injury (TBI) that increases health risks and mortality rates; researchers within the EpiBioS4Rx study aim to find therapies to prevent PTE in rat models.
- - The study focuses on sodium selenate, which has shown promise in reducing seizure development post-TBI by acting on specific proteins in the brain; experiments measure how the drug is processed in rats' bodies and its effectiveness in reaching the brain.
- - Results indicate that sodium selenate undergoes rapid transformation in the body and demonstrates complex clearance and distribution patterns, suggesting it effectively crosses the blood-brain barrier, which is crucial for its potential as a therapeutic agent.
An International Delphi Consensus on the Management of Pollen-Food Allergy Syndrome: A Work Group Report of the AAAAI Adverse Reactions to Foods Committee.
J Allergy Clin Immunol Pract
December 2024
Royal Brompton & Harefield Hospitals, part of Guys & St. Thomas National Health Services (NHS) Foundation Trust, London, UK.
Article Synopsis
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