Chemical examination of the octocoral-associated species (sp.) DT001 led to the isolation of pumilacidins A () and C (). We investigated the effect of these compounds on the viability of and the mechanism of pumilacidin-induced death. The use of inhibitors of protein kinase C (PKC) and phosphoinositide 3-kinase (PI3K) was able to prevent the effects of pumilacidins A and C. The results indicated also that pumilacidins inhibit parasite growth via mitochondrial dysfunction and decreased cytosolic Ca.
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| http://dx.doi.org/10.3390/molecules23092179 | DOI Listing |
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